(S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate
• CAS No.: 869377-95-7
• Molecular Formula: C₁₈H₂₈N₂O₂
• Molecular Weight: 304.433
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30468699
• Wikidata: Q82296042
• Mol file: 869377-95-7.mol

Synonyms:869377-95-7;(S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate;(S)-1-N-Boc-2-Phenyl-1-pyrrolidin-1-ylmethyl-ethylamine;(S)-(2-PHENYL-1-PYRROLIDIN-1-YLMETHYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;(S)-tert-butyl 1-phenyl-3-(pyrrolidin-1-yl)propan-2-ylcarbamate;tert-butyl N-[(2S)-1-phenyl-3-pyrrolidin-1-ylpropan-2-yl]carbamate;DTXSID30468699;(S)-tert-Butyl(1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate;MFCD11501183;2-Methyl-2-propanyl [(2S)-1-phenyl-3-(1-pyrrolidinyl)-2-propanyl]carbamate;AKOS015998805;CS-0171854;A848471;(S)-1-N-Boc-2-Phenyl-1-Pyrrolidin-1-Ylmethylethylamine;tert-Butyl(S)-(1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate;tert-Butyl [(2S)-1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl]carbamate;(S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbaMate;(S)-1-N-BOC-2-PHENYL-1-PYRROLIDIN-1-YLMETHYL-ETHYLAMINE

Chemical Property of (S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate

Chemical Property:

• PSA: 41.57000
• LogP: 3.54700
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 304.215078140
• Heavy Atom Count: 22
• Complexity: 340

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl1-phenyl-3-(pyrrolidin-1-yl)propan-2-ylcarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)CN2CCCC2
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)CN2CCCC2

Technology Process of (S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate

There total 7 articles about (S)-tert-Butyl (1-phenyl-3-(pyrrolidin-1-yl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate (126301-19-7,134807-64-0,109687-66-3) → (S)-tert-butyl 1-phenyl-3-(pyrrolidin-1-yl)propan-2-ylcarbamate (869377-95-7)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 40h; Inert atmosphere;

DOI:10.1039/c6ra14016e

Reference yield: 39.0%

Nα-(tert-butoxycarbonyl)-L-phenylalanine-N-pyrrolidinamide (125139-05-1) → (S)-tert-butyl 1-phenyl-3-(pyrrolidin-1-yl)propan-2-ylcarbamate (869377-95-7)

Guidance literature:

With borane; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/jo051313l

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-tert-butyl 1-phenyl-3-(pyrrolidin-1-yl)propan-2-ylcarbamate (869377-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*PF₆; diisopropylethylamine / dimethylformamide / 1 h / 20 °C

1.2: 80 percent / dimethylformamide / 1 h

2.1: 39 percent / BH₃ / tetrahydrofuran / 18 h / 20 °C

With borane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo051313l

upstream raw materials:

N^α-(tert-butoxycarbonyl)-L-phenylalanine-N-pyrrolidinamide

N-tert-butoxycarbonyl-L-phenylalanine

pyrrolidine

(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 869377-95-7 (S)-(2-PHENYL-1-PYRROLIDIN-1-YLMETHYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send