Chemical Property of Ganirelix
Chemical Property:
- Purity/Quality:
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99%, *data from raw suppliers
Ganirelix acetate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Therapeutic Function
LHRH antagonist
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Clinical Use
Ganirelix acetate is an analog of GnRH with substitutions at residues 1, 2, 3, 6, 8, and 10. It is not a superagonist but, rather, is a synthetic decapeptide with high antagonist
activity and the first GnRH antagonist to be marketed. It is approved for the suppression of LH
surges in women who are undergoing ovarian hyperstimulation fertility treatment; LH surges
normally promote ovulation. The goal of this drug is to significantly reduce the number of
medication days necessary to suppress the LH surge, thereby maintaining eggs in the ovaries.
In vitro fertilization (IVF) treatment cycles were historically initiated by the administration of
leuprolide acetate to suppress the premature release of LH. This inhibits ovulation so that the
eggs remain available for retrieval by a fertility specialist. For this purpose, leuprolide acetate usually is injected for as many as 26 days. Clinical studies have shown that ganirelix acetate
can shut down the LH surge in only 5 days of treatment, that the suppression of LH is more
pronounced than that of FSH, and that the shorter treatment time minimizes unpleasant side
effects, such as hot flashes and headaches.
