[2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid

Base Information

Chemical Name:[2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid
CAS No.:159119-10-5
Molecular Formula:C15H22BFO2
Molecular Weight:264.14300
Hs Code.:
European Community (EC) Number:605-173-1
DSSTox Substance ID:DTXSID301187430
Mol file:159119-10-5.mol

Synonyms:159119-10-5;[2-fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid;(2-Fluoro-4-(trans-4-propylcyclohexyl)phenyl)boronic acid;B-[2-fluoro-4-(trans-4-propylcyclohexyl)phenyl]Boronic acid;2-Fluoro-4-(trans-4-propylcyclohexyl)phenylboronic acid;Boronic acid, B-[2-fluoro-4-(trans-4-propylcyclohexyl)phenyl]-;(2-fluoro-4-(4-propylcyclohexyl)phenyl)boronic acid;{2-fluoro-4-[(1s,4r)-4-propylcyclohexyl]phenyl}boronic acid;2-FLUORO-4-(4-PROPYLCYCLOHEXYL)PHENYLBORONIC ACID;SCHEMBL2392780;SCHEMBL6558027;DTXSID301187430;SB67067;2-Fluoro-4-(trans-propylcyclohexyl)phenylboronicacid;J-519663;(2-Fluoro-4-(trans-4-propylcyclohexyl)phenyl)boronicacid

Suppliers and Price of [2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2-Fluoro-4-(trans-4-propylcyclohexyl)phenyl)boronicacid 97%
5g
$ 982.00

Crysdot
(2-Fluoro-4-(trans-4-propylcyclohexyl)phenyl)boronicacid 97%
1g
$ 327.00

Total 48 raw suppliers

Chemical Property of [2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid

Chemical Property:

Boiling Point:389.0±52.0 °C(Predicted)
PKA:8.50±0.58(Predicted)
PSA：40.46000
Density:1.09±0.1 g/cm3 (20 oC 760 Torr)
LogP:2.57940
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:264.1696883
Heavy Atom Count:19
Complexity:267

Purity/Quality:

97% ^*data from raw suppliers

(2-Fluoro-4-(trans-4-propylcyclohexyl)phenyl)boronicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:B(C1=C(C=C(C=C1)C2CCC(CC2)CCC)F)(O)O

Technology Process of [2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid

There total 4 articles about [2-Fluoro-4-(4-propylcyclohexyl)phenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 119511-09-0,138679-81-9
4-Propyl-1-(3-fluorophenyl)-cyclohexane

: 159119-10-5
2-fluoro-4-(4-propylcyclohexyl)-phenylboronic acid

Guidance literature:: 4-Propyl-1-(3-fluorophenyl)-cyclohexane; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -74 - -70 ℃; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; cyclohexane; at -74 - 25 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; hexane; cyclohexane; Inert atmosphere; Cooling with ice;

Reference yield: 65.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 7732-18-5
water

: 119511-09-0,138679-81-9
4-Propyl-1-(3-fluorophenyl)-cyclohexane

: 159119-10-5
2-fluoro-4-(4-propylcyclohexyl)-phenylboronic acid

Guidance literature:: 4-Propyl-1-(3-fluorophenyl)-cyclohexane; With n-butyllithium; In tetrahydrofuran; at -80 ℃; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; Inert atmosphere;

water; With hydrogenchloride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 159119-10-5
2-fluoro-4-(4-propylcyclohexyl)-phenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4 h / Reflux

2.1: n-butyllithium / tetrahydrofuran / -80 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In tetrahydrofuran; ethanol; water; toluene; 1.1: |Suzuki Coupling;