4,6-Dichloro-5-iodopyrimidine

Base Information

• Chemical Name: 4,6-Dichloro-5-iodopyrimidine
• CAS No.: 1137576-38-5
• Molecular Formula: C4HCl2IN2
• Molecular Weight: 274.876
• Hs Code.: 2933599090
• Mol file: 1137576-38-5.mol

Synonyms:4,6-dichloro-5-iodo-pyrimidine;

Chemical Property of 4,6-Dichloro-5-iodopyrimidine

Chemical Property:

• Melting Point: 134.9-136.5 °C
• Boiling Point: 313.9±37.0 °C(Predicted)
• PKA: -5.65±0.26(Predicted)
• PSA: 25.78000
• Density: 2 +-.0.06 g/cm3(Predicted)
• LogP: 2.38800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dichloro-5-iodopyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Dichloro-5-iodopyrimidine

There total 1 articles about 4,6-Dichloro-5-iodopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4,6-dichloropyrimidine (1193-21-1) → 4,6-dichloro-5-iodo-pyrimidine (1137576-38-5)

Guidance literature:

4,6-dichloropyrimidine; With bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

With iodine; In tetrahydrofuran; at 25 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.200801831

Reference yield: 80.0%

4,6-dichloro-5-iodo-pyrimidine (1137576-38-5) + 2,4-Dimethoxybenzylamine (20781-20-8) → 6-chloro-N-(2,4-dimethoxybenzyl)-5-iodopyrimidin-4-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 60 ℃; for 3h;

DOI:10.1021/acs.jmedchem.9b01916

Reference yield: 80.0%

4,6-dichloro-5-iodo-pyrimidine (1137576-38-5) → 6-amino-4-chloro-5-iodopyrimidine (353272-15-8)

Guidance literature:

With ammonium hydroxide; In water; isopropyl alcohol; at 70 ℃; for 15h; Autoclave;

DOI:10.1021/acs.jmedchem.9b01916

upstream raw materials:

4,6-dichloropyrimidine

Downstream raw materials:

tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

6-amino-4-chloro-5-iodopyrimidine

Refernces

• 1、 -. "PRODUCTION AND USE OF ZINC AMIDES". Page/Page column 10. . Retrieved 2011/12/12.
• 2、 Mosrin, Marc,Knochel, Paul. "TMPZnCI.LiCI: A new active selective base for the directed zincation of sensitive aromatics and heteroaromatics". supporting information; experimental part. p. 1837 - 1840. Retrieved 2009/09/05.