2,4-Dimethoxybenzylamine

Base Information

• Chemical Name: 2,4-Dimethoxybenzylamine
• CAS No.: 20781-20-8
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Hs Code.: 29222990
• Mol file: 20781-20-8.mol

Synonyms:Benzenemethanamine, 2,4-dimethoxy-;(2,4-dimethoxyphenyl)methanamine;2,4-Dimethoxy benzyl amine;

Chemical Property of 2,4-Dimethoxybenzylamine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 0.00611mmHg at 25°C
• Refractive Index: n20/D 1.549(lit.)
• Boiling Point: 271 °C at 760 mmHg
• PKA: 9.39±0.10(Predicted)
• Flash Point: 127.5 °C
• PSA: 44.48000
• Density: 1.062 g/cm³
• LogP: 1.86280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dimethoxybenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,4-Dimethoxybenzylamine is an amine nucleophile used to investigate the 1,4- reactivity of 5-bromo-2-indene-1-one. It may be used in the following studies: As an ammonia equivalent in the concise synthesis of a series of 2,4,5-trisubstituted oxazoles, via a tandem Ugi/Robinson-Gabriel reaction sequence.Total synthesis of (-)-muraymycin (MRY) D2 and its epimer, the antibacterial nucleoside natural product. Two-step synthesis of amide derivatives of uracil polyoxin C (UPOC) methyl ester using the Ugi reaction. Synthesis of N-hydroxythiourea.Synthesis of anti-HIV-1 agents.

Technology Process of 2,4-Dimethoxybenzylamine

There total 7 articles about 2,4-Dimethoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-dimethoxybenzaldoxime (31874-34-7) → 2,4-Dimethoxybenzylamine (20781-20-8)

Guidance literature:

With borohydride exchange resin; nickel diacetate; In methanol; at 65 ℃; for 13h;

DOI:10.1080/00397919508013422

Reference yield: 83.0%

2,4-dimethoxybenzonitrile (4107-65-7) → 2,4-Dimethoxybenzylamine (20781-20-8) + bis(2,4-dimethoxybenzyl)amine (20781-23-1)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In ethanol; at 20 ℃; for 0.0833333h;

DOI:10.1081/SCC-120003619

Reference yield:

C20H24N2O6 → 2,4-Dimethoxybenzylamine (20781-20-8)

Guidance literature:

With potassium tert-butylate; hydrogen; [Ru(P^tBuNNH^Bn)H(CO)Cl]; In toluene; at 135 ℃; for 24h; under 30003 Torr;

DOI:10.1039/d0sc02065f

upstream raw materials:

2,4-dimethoxybenzaldoxime

2,4-dimethoxybenzonitrile

2,4-Dimethoxybenzaldehyde

2,4-dimethoxybenzylamine hydrochloride

Downstream raw materials:

1-(isothiocyanatomethyl)-2,4-dimethoxy benzene

Methyl N-(2,4-dimethoxybenzyl)iminoacetate

(1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,5,6,7,8,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2,4-dimethoxy-benzylamide

(1S,8R,10R,11R)-1,11-Dihydroxy-3,6-dimethoxy-10-methyl-9-oxa-tricyclo[6.2.2.0^2,7]dodeca-2,4,6-triene-5-carboxylic acid 2,4-dimethoxy-benzylamide