5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

Base Information

• Chemical Name: 5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid
• CAS No.: 1171919-98-4
• Molecular Formula: C7H7NO4
• Molecular Weight: 169
• Hs Code.: 2933399090
• Mol file: 1171919-98-4.mol

Synonyms:5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid;6-Hydroxy-5-Methoxypyridine-3-carboxylic acid hydrochloride

Chemical Property of 5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

Chemical Property:

• PSA: 79.65000
• LogP: 0.49400
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Hydroxy-5-methoxynicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

There total 1 articles about 5-Methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

carbon dioxide (124-38-9,18923-20-1) + 5-bromo-3-methoxypyridin-2(1H)-one (1189757-62-7) → 5-methoxy-6-oxo-1,6-dihydropyridine-3-carboxylic acid (1171919-98-4)

Guidance literature:

5-bromo-3-methoxypyridin-2(1H)-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; water;

DOI:10.1016/j.bmc.2009.05.069

Reference yield: 34.8%

5-methoxy-6-oxo-1,6-dihydropyridine-3-carboxylic acid (1171919-98-4) + 4-[chloro(difluoro)methoxy]aniline (39065-95-7) → N-[4-[chloro(difluoro)methoxy]phenyl]-5-methoxy-6-oxo-1H-pyridine-3-carboxamide

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; Reflux;

Reference yield:

5-methoxy-6-oxo-1,6-dihydropyridine-3-carboxylic acid (1171919-98-4) + (S)-N-((R)-(2-(allyloxy)-5-chloro-4-methylphenyl)(piperidin-4-yl)methyl)-2-methylpropane-2-sulfinamide → (S)-N-[(R)-[5-chloro-4-methyl-2-(prop-2-en-1-yloxy)phenyl][1-(5-methoxy-6-oxo-1H-pyridine-3-carbonyl)piperidin-4-yl]methyl]-2-methylpropane-2-sulfinamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

carbon dioxide

5-bromo-3-methoxypyridin-2(1H)-one

Refernces