5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
• CAS No.: 916325-85-4
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.032
• Hs Code.: 2933990090
• Mol file: 916325-85-4.mol

Synonyms:1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, 5-bromo-;

Chemical Property of 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.785
• Boiling Point: 492.256 °C at 760 mmHg
• PKA: 1.89±0.30(Predicted)
• Flash Point: 251.507 °C
• PSA: 78.87000
• Density: 2.068g/cm³
• LogP: 1.41860
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

There total 10 articles about 5-Bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate (916325-84-3) → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (916325-85-4)

Guidance literature:

With sodium hydroxide; In methanol; for 4h; Heating;

DOI:10.1016/j.bmcl.2007.05.029

Reference yield: 100.0%

5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine (875781-18-3) + carbon monoxide (201230-82-2) → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (916325-85-4)

Guidance literature:

With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 60 ℃; for 8h;

DOI:10.1016/j.ejmech.2021.113371

Reference yield:

5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine (885223-65-4,916258-22-5) → 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (916325-85-4)

Guidance literature:

With potassium permanganate; sodium hydroxide; In water; at 100 ℃; for 3h;

DOI:10.1021/ic201704u

upstream raw materials:

methyl 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester

5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine

3-methyl-1H-pyrazolo[3,4b]pyridine

Downstream raw materials:

C₁₅H₁₄O₂N₅Br

C₁₈H₂₀N₇OBr

C₁₇H₁₇N₆O₂Br

C₂₀H₂₆N₅O₂BrSi

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