benzyl (6-Azaspiro[2.5]octan-1-yl)carbamate

Base Information

• Chemical Name: benzyl (6-Azaspiro[2.5]octan-1-yl)carbamate
• CAS No.: 1239852-33-5
• Molecular Formula: C15H20N2O2
• Molecular Weight: 260.336
• Mol file: 1239852-33-5.mol

Synonyms:QC-1851;benzyl 6-azaspiro[2.5]octan-1-ylcarbamate;benzyl (6-azaspiro[2.5]oct-1-yl)carbamate;

Chemical Property of benzyl (6-Azaspiro[2.5]octan-1-yl)carbamate

Chemical Property:

• PSA: 53.85000
• Density: 1.18±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 2.58810

Purity/Quality:

97% ^*data from raw suppliers

Benzyl 6-azaspiro[2.5]octan-1-ylcarbamate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl (6-Azaspiro[2.5]octan-1-yl)carbamate

There total 4 articles about benzyl (6-Azaspiro[2.5]octan-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate (1239852-32-4) → benzyl 6-azaspiro[2.5]octan-1-ylcarbamate (1239852-33-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.75h;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → benzyl 6-azaspiro[2.5]octan-1-ylcarbamate (1239852-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 0 - 110 °C

1.2: 2 h / 110 °C

2.1: trifluoroacetic acid / dichloromethane / 1.75 h / 20 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid (871727-05-8) → benzyl 6-azaspiro[2.5]octan-1-ylcarbamate (1239852-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 0 - 110 °C

1.2: 2 h / 110 °C

2.1: trifluoroacetic acid / dichloromethane / 1.75 h / 20 °C

With diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

upstream raw materials:

benzyl alcohol

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate