tert-Butyl 1-benzyloxycarbonylaMino-6-azaspiro[2.5]octane-6-carboxylate

Base Information

• Chemical Name: tert-Butyl 1-benzyloxycarbonylaMino-6-azaspiro[2.5]octane-6-carboxylate
• CAS No.: 1239852-32-4
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453
• Mol file: 1239852-32-4.mol

Synonyms:tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

Chemical Property of tert-Butyl 1-benzyloxycarbonylaMino-6-azaspiro[2.5]octane-6-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl1-(((benzyloxy)carbonyl)amino)-6-azaspiro[2.5]octane-6-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 1-benzyloxycarbonylaMino-6-azaspiro[2.5]octane-6-carboxylate

There total 1 articles about tert-Butyl 1-benzyloxycarbonylaMino-6-azaspiro[2.5]octane-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid (871727-05-8) + benzyl alcohol (100-51-6,185532-71-2) → tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate (1239852-32-4)

Guidance literature:

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 0 - 110 ℃; for 2h;

benzyl alcohol; In toluene; at 110 ℃; for 2h;

Reference yield: 48.0%

tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate (1239852-32-4) → benzyl 6-azaspiro[2.5]octan-1-ylcarbamate (1239852-33-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.75h;

Reference yield:

tert-butyl 1-(benzyloxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate (1239852-32-4) → benzyl 6-(3-(2-chlorophenyl)-1H-pyrazolo[4,3-b]pyrazin-6-yl)-6-azaspiro[2.5]octan-1-ylcarbamate

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1.75 h / 20 °C

2: potassium phosphate / 1-methyl-pyrrolidin-2-one / 13 h / 90 °C

With potassium phosphate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

upstream raw materials:

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

benzyl alcohol

Downstream raw materials:

benzyl 6-azaspiro[2.5]octan-1-ylcarbamate