6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID
• CAS No.: 907211-31-8
• Molecular Formula: C13H12FNO2
• Molecular Weight: 233.24
• Hs Code.: 2933990090
• Mol file: 907211-31-8.mol

Synonyms:6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID

Chemical Property of 6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID

Chemical Property:

• PSA: 53.09000
• LogP: 2.49650

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic Acid is a useful reagent in the synthesis of WAY-253752, a novel, dual-acting SSRI/5HT1A antagonist.

Technology Process of 6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID

There total 4 articles about 6-FLUORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid ethyl ester (322725-63-3) → 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (907211-31-8)

Guidance literature:

6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid ethyl ester; With potassium hydroxide; In ethanol; at 40 - 45 ℃; for 3h;

With hydrogenchloride; In ethanol; water; Product distribution / selectivity;

Reference yield: 97.5%

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (907211-31-8)

Guidance literature:

ethyl 4-oxocyclohexane-1-carboxylate; 4-fluorophenyhydrazine hydrochloride; In ethanol; at 40 - 82 ℃; for 2h;

With sodium hydroxide; In ethanol; water; at 40 - 82 ℃; for 1h;

With hydrogenchloride; In ethanol; water; at 20 - 70 ℃; for 1.33333h; Product distribution / selectivity;

Reference yield:

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) → 6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (907211-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 16 h / Reflux

2: potassium hydroxide / ethanol / 3 h / 40 - 45 °C / Inert atmosphere

With potassium hydroxide; In ethanol;

DOI:10.1021/op700181n

upstream raw materials:

ethyl 4-oxocyclohexane-1-carboxylate

4-fluorophenyhydrazine hydrochloride

6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid ethyl ester