322725-63-3Relevant academic research and scientific papers
First scale-up: Problems and resolutions on the synthesis of WAY-253752, a novel, dual-acting SSRI/5HT1A antagonist
Nikitenko, Antonia,Evrard, Deborah,Sabb, Annmarie L.,Vogel, Robert L.,Stack, Gary,Young, Mairead,Lin, Melissa,Harrison, Boyd L.,Potoski, John R.
, p. 76 - 80 (2008)
An alternative synthesis of WAY-253752, 1, a novel, dual-acting SSRI/5HT1A antagonist, was developed and used for the first scale-up. Initially, the target compound was synthesized as part of a diasteromeric mixture separated by chiral preparative HPLC. The new route was designed around intermediates suitable for chiral resolution, and its conditions were successfully determined.
Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2
Hatzenbuhler, Nicole T.,Baudy, Reinhardt,Evrard, Deborah A.,Failli, Amedeo,Harrison, Boyd L.,Lenicek, Steven,Mewshaw, Richard E.,Saab, Annmarie,Shah, Uresh,Sze, Jean,Zhang, Minsheng,Zhou, Dahui,Chlenov, Michael,Kagan, Michael,Golembieski, Jeannette,Hornby, Geoffrey,Lai, Margaret,Smith, Deborah L.,Sullivan, Kelly M.,Schechter, Lee E.,Andree, Terrance H.
experimental part, p. 6980 - 7004 (2009/11/30)
Novel compounds combining a 5-HT1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1- or 3-position of the indole were evaluated for dual affin
CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES
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Page/Page column 34-35; 28, (2008/06/13)
The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and mo
3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES
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Page/Page column 76a, (2010/02/10)
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity
Block, Michael H.,Boyer, Scott,Brailsford, Wayne,Brittain, David R.,Carroll, Debra,Chapman, Steve,Clarke, David S.,Donald, Craig S.,Foote, Kevin M.,Godfrey, Linda,Ladner, Anthony,Marsham, Peter R.,Masters, David J.,Mee, Christine D.,O'Donovan, Michael R.,Pease, J. Elizabeth,Pickup, Adrian G.,Rayner, John W.,Roberts, Andrew,Schofield, Paul,Suleman, Abid,Turnbull, Andrew V.
, p. 3509 - 3523 (2007/10/03)
The hypothesis that antagonists of the neuropeptide Y5 receptor would provide safe and effective appetite suppressants for the treatment of obesity has prompted vigorous research to identify suitable compounds. We discovered a series of acylated aminocarb
