(S)-4-Methylpyrrolidin-2-one

Base Information

Chemical Name:(S)-4-Methylpyrrolidin-2-one
CAS No.:31551-66-3
Molecular Formula:C5H9NO
Molecular Weight:99.1326
Hs Code.:
DSSTox Substance ID:DTXSID40434027
Nikkaji Number:J522.037H
Wikidata:Q82248323
Mol file:31551-66-3.mol

Synonyms:(S)-4-Methylpyrrolidin-2-one;31551-66-3;(4S)-4-METHYLPYRROLIDIN-2-ONE;DTXSID40434027;(4S)-4-Methylpyrrolidine-2-one;MFCD19217125;2-Pyrrolidinone, 4-methyl-, (S)-;AKOS006347271;AS-60902;CS-0053172;P17327;EN300-2975497;A934104

Suppliers and Price of (S)-4-Methylpyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of (S)-4-Methylpyrrolidin-2-one

Chemical Property:

XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:99.068413911
Heavy Atom Count:7
Complexity:90.1

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(=O)NC1
Isomeric SMILES:C[C@H]1CC(=O)NC1

Technology Process of (S)-4-Methylpyrrolidin-2-one

There total 5 articles about (S)-4-Methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 492435-27-5
(2S,5S)-N-allyl-2-(tert-butyldimethylsilyl)oxy-2-bromomethyl-5-phenyl-1,3-oxazolidin-4-one

: 31551-66-3
(S)-(-)-4-methylpyrrolidin-2-one

: 17199-29-0
(S)-Mandelic acid

: 260061-31-2
(R)-(+)-4-methylpyrrolidin-2-one

Guidance literature:: (2S,5S)-N-allyl-2-(tert-butyldimethylsilyl)oxy-2-bromomethyl-5-phenyl-1,3-oxazolidin-4-one; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 0 ℃; for 12h; UV-irradiation;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(03)01015-9

Reference yield:

: (S)-methyl 4-[(S)-2-methoxymethylpyrrolidin-1-ylimino]-3-methylbutanoate

: 31551-66-3
(S)-(-)-4-methylpyrrolidin-2-one

: 260061-31-2
(R)-(+)-4-methylpyrrolidin-2-one

Guidance literature:: (S)-methyl 4-[(S)-2-methoxymethylpyrrolidin-1-ylimino]-3-methylbutanoate; With magnesium monoperoxyphthalate hexahydrate; In methanol; phosphate buffer; at 0 ℃; pH=7;

With hydrogen; nickel; In methanol; at 70 ℃; for 16h; under 15001.2 Torr; Title compound not separated from byproducts;
DOI:10.3987/COM-05-S(K)41

Reference yield:

: 1-((S)-2-Hydroxy-1-phenyl-ethyl)-4-methyl-pyrrolidin-2-one

: 31551-66-3
(S)-(-)-4-methylpyrrolidin-2-one

: 260061-31-2
(R)-(+)-4-methylpyrrolidin-2-one

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; ethanol; for 0.166667h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00053a012