3-Azabicyclo[3.2.0]heptane

Base Information

• Chemical Name: 3-Azabicyclo[3.2.0]heptane
• CAS No.: 278-08-0
• Molecular Formula: C6H11N
• Molecular Weight: 97.16
• Hs Code.: 2933990090
• Mol file: 278-08-0.mol

Synonyms:3-azabicyclo[0.2.3]heptane;3-Aza-bicyclo[3.2.0]heptane;1-Azabicyclo<3-Azabicyclo<3.2.0>heptan;

Chemical Property of 3-Azabicyclo[3.2.0]heptane

Chemical Property:

• Boiling Point: 135-137 °C
• PKA: 11.44±0.20(Predicted)
• PSA: 12.03000
• Density: 0.959±0.06 g/cm3(Predicted)
• LogP: 0.94460

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-AZABICYCLO[3.2.0]HEPTANE HCL 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Azabicyclo[3.2.0]heptane

There total 4 articles about 3-Azabicyclo[3.2.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diallylamine (124-02-7) → 3-azabicyclo[3.2.0]heptane Hydrochloride (278-08-0)

Guidance literature:

diallylamine; (^IPr2,6-(2,6-iPr₂C₆H₃N=CMe)₂C₅H₃N)Fe(N₂)₂; In toluene; under 18 Torr;

With carbon monoxide; In benzene-d6; for 1h; under 3040 Torr;

DOI:10.1021/ja064711u

Reference yield:

C13H17N → 3-azabicyclo[3.2.0]heptane Hydrochloride (278-08-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 12h; under 45603.1 Torr;

DOI:10.1021/acs.joc.8b00077

Reference yield:

3-benzyl-3-azabicyclo[3.2.0]heptane-2,4-dione → 3-azabicyclo[3.2.0]heptane Hydrochloride (278-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 40 °C / 45603.1 Torr

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1021/acs.joc.8b00077

upstream raw materials:

diallylamine

Refernces

• 1、 -. "CYCLOBUTENEDIONE DERIVATIVES". Page/Page column 81. . Retrieved 2010/12/17.