(2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine

Base Information

• Chemical Name: (2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine
• CAS No.: 745031-35-0
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.315
• Mol file: 745031-35-0.mol

Synonyms:(2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine;(2S,5S)-1-benzyl-2,5-diMethylpiperazine dihydrochloride;(2S,5S)-2,5-Dimethyl-1-(phenylmethyl)piperazine;Piperazine, 2,5-diMethyl-1-(phenylMethyl)-, (2S,5S)-

Chemical Property of (2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine

Chemical Property:

• Boiling Point: 292℃
• Flash Point: 110℃
• PSA: 15.27000
• Density: 0.964
• LogP: 2.13550

Purity/Quality:

97% ^*data from raw suppliers

(2S,5S)-1-Benzyl-2,5-dimethyl-piperazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine

There total 24 articles about (2S,5S)-1-Benzyl-2,5-Dimethyl-Piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (431062-00-9) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1h; Product distribution / selectivity;

Reference yield: 99.0%

(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione (1072102-01-2) → (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 80 ℃; for 5.66667h; Cooling with ice; Inert atmosphere;

Reference yield: 81.0%

C13H20N2 (3138-88-3,324750-43-8,745031-35-0) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

C₁₃H₂₀N₂; With L-Tartaric acid; In methanol; at 0 - 20 ℃; for 24.33h;

With sodium carbonate; In water; pH=9 - 10; Purification / work up;

upstream raw materials:

benzyl bromide

2,5-dimethyl-piperazine

(+/-)-trans-2,5-dimethyl-4-benzyl-piperazine

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

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