2',4'-DICHLORO-3-PHENYLPROPIOPHENONE

Base Information

• Chemical Name: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE
• CAS No.: 898788-78-8
• Molecular Formula: C₁₅H₁₂Cl₂O
• Molecular Weight: 279.166
• Hs Code.: 2914700090
• Mol file: 898788-78-8.mol

Synonyms:2,4-DICHLORO-3-PHENYLPROPIOPHENONE

Chemical Property of 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 1.19E-06mmHg at 25°C
• Refractive Index: 1.592
• Boiling Point: 401.3°C at 760 mmHg
• Flash Point: 169.6°C
• PSA: 17.07000
• Density: 1.257g/cm³
• LogP: 4.80890

Purity/Quality:

97% ^*data from raw suppliers

2',4'-dichloro-3-phenylpropiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE

There total 6 articles about 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

trans-1-(2,4-dichlorophenyl)-3-phenylprop-2-en-1-one → 1-(2,4-dichlorophenyl)-3-phenylpropan-1-one (898788-78-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 4h; Time; Reflux;

DOI:10.1080/00397911.2013.813053

Reference yield: 58.0%

trans-1-(2,4-dichlorophenyl)-3-phenylprop-2-en-1-one → 5-chloro-3-phenyl-2,3-dihydro-1H-inden-1-one (65565-17-5) + 1-(2,4-dichlorophenyl)-3-phenylpropan-1-one (898788-78-8)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 16h; Reflux;

DOI:10.1080/00397911.2013.813053

Reference yield:

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → 1-(2,4-dichlorophenyl)-3-phenylpropan-1-one (898788-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 3 h / Reflux

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 4 h / Reflux

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; potassium hydroxide; In ethanol; benzene;

DOI:10.1080/00397911.2013.813053

upstream raw materials:

1-(2,4-dichlorophenyl)ethan-1-one

benzaldehyde

Downstream raw materials:

5-benzyl-4-(2,4-dichlorophenyl)thiazol-2-amine

5-benzyl-4-(2,4-dichlorophenyl)-N-(4-methoxybenzyl)thiazol-2-amine

Refernces

• 1、 Xu, Zhongliang,Ba, Mingyu,Zhou, Hua,Cao, Yingli,Tang, Chaojun,Yang, Ying,He, Ricai,Liang, Yu,Zhang, Xuemei,Li, Zhenzhong,Zhu, Lihong,Guo, Ying,Guo, Changbin. "2,4,5-Trisubstituted thiazole derivatives: A novel and potent class of non-nucleoside inhibitors of wild type and mutant HIV-1 reverse transcriptase". . p. 27 - 42. Retrieved 2014/08/18.