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2234-16-4

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2234-16-4 Usage

Chemical Properties

Colorless to yellow-brown solid

Uses

2′,4′-Dichloroacetophenone was used in the synthesis of the Schiff base derivatives.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 2234-16-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,3 and 4 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2234-16:
(6*2)+(5*2)+(4*3)+(3*4)+(2*1)+(1*6)=54
54 % 10 = 4
So 2234-16-4 is a valid CAS Registry Number.

2234-16-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Detail
  • Alfa Aesar

  • (A14428)  2',4'-Dichloroacetophenone, 98%   

  • 2234-16-4

  • 25g

  • 490.0CNY

  • Detail
  • Alfa Aesar

  • (A14428)  2',4'-Dichloroacetophenone, 98%   

  • 2234-16-4

  • 100g

  • 1348.0CNY

  • Detail
  • Alfa Aesar

  • (A14428)  2',4'-Dichloroacetophenone, 98%   

  • 2234-16-4

  • 500g

  • 4706.0CNY

  • Detail

2234-16-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,4-dichlorophenyl)ethanone

1.2 Other means of identification

Product number -
Other names 2,4-dichoroacetophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2234-16-4 SDS

2234-16-4Synthetic route

acetic anhydride
108-24-7

acetic anhydride

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With aluminum (III) chloride at 40 - 55℃;97.9%
Stage #1: acetic anhydride; 1,3-Dichlorobenzene With aluminum (III) chloride at 40 - 55℃; under 637.564 Torr;
Stage #2: With hydrogenchloride In water
95%
With aluminum (III) chloride at 50℃; for 4h; Reagent/catalyst; Temperature;70.9%
Stage #1: acetic anhydride With aluminum (III) chloride In 1,2-dichloro-benzene for 0.333333h;
Stage #2: 1,3-Dichlorobenzene With hydrogenchloride In water; 1,2-dichloro-benzene Cooling with ice;
55.46%
With hydrogenchloride; aluminum (III) chloride; calcium chloride In water for 0.833333h;55.46%
acetyl chloride
75-36-5

acetyl chloride

1,3-Dichlorobenzene
541-73-1

1,3-Dichlorobenzene

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
at 60℃; for 4h; Ionic liquid; Green chemistry;96%
at 60℃; for 4h; Temperature; Ionic liquid;96%
With aluminium trichloride
2,4-dichloro-α-methylbenzyl alcohol
1475-13-4

2,4-dichloro-α-methylbenzyl alcohol

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; iodine; sodium hydrogencarbonate In dichloromethane; water at 20 - 22℃; for 3h; Reagent/catalyst;95%
With copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium tert-butylate; L-proline In N,N-dimethyl-formamide at 25℃; for 8h;90%
With calcomenite; potassium hydroxide In toluene for 24h; Reflux;86%
2,4-dichlorostyrene
2123-27-5

2,4-dichlorostyrene

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With perchloric acid; oxygen; palladium diacetate; p-benzoquinone; sodium nitrite In methanol; water at 20℃; for 24h; Wacker Oxidation; Schlenk technique; Sealed tube; Green chemistry;94%
With dihydrogen peroxide In water; acetonitrile at 55℃; for 12h; Wacker Oxidation;62%
With manganese(IV) oxide; palladium dichloride In water; acetonitrile at 60℃; for 28h;60%
2,2',4'-trichloroacetophenone
4252-78-2

2,2',4'-trichloroacetophenone

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With tris-(trimethylsilyl)silane In acetonitrile for 24h; Schlenk technique; Inert atmosphere; Irradiation;91%
1-(2,4-dichlorophenyl)ethan-1-one oxime
71516-67-1

1-(2,4-dichlorophenyl)ethan-1-one oxime

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With hydrogenchloride; sodium chlorite In water at 20℃; for 0.0833333h;91%
With Iron(III) nitrate nonahydrate; oxygen In toluene at 37℃; under 760.051 Torr; for 1.5h; Schlenk technique; Green chemistry;91%
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)
68107-01-7

O,O-dimethyl-O-<1-(2,4-dichlorophenyl)-2-bromo>vinyl phosphate (isomer Z)

B

2,4-dichlorophenacyl-O,O-dimethylphosphonate

2,4-dichlorophenacyl-O,O-dimethylphosphonate

C

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
In methanol for 0.25h; Title compound not separated from byproducts;A 90%
B 3.3%
C 3.3%
In methanol for 0.25h; Mechanism; Heating; other phenacyl and phenacylidene halides;
2,4-dichlorophenylboronic acid
68716-47-2

2,4-dichlorophenylboronic acid

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 90℃; for 8h; regioselective reaction;70%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2,4-dichlorobenzylnitrile
6574-98-7

2,4-dichlorobenzylnitrile

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With diethyl ether anschliessendes Behandeln mit wss. H2SO4;
Phosphorsaeure-<1-(2,4-dichlor-phenyl)-vinylester>-diisopropylester
15289-82-4

Phosphorsaeure-<1-(2,4-dichlor-phenyl)-vinylester>-diisopropylester

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid
With sulfuric acid at 165℃;
Methyl 3,3-dimethylacrylate
924-50-5

Methyl 3,3-dimethylacrylate

2,4-dichlorobenzoyl chloride
89-75-8

2,4-dichlorobenzoyl chloride

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
(i) AlCl3, (ii) NaOH, MeOH; Multistep reaction;
2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

A

2-bromo-1-(2,4-dichlorophenyl)ethanol
53066-15-2

2-bromo-1-(2,4-dichlorophenyl)ethanol

B

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With 9,10-dihydro-10-methylacridine; perchloric acid In acetonitrile at 61.9℃; Product distribution; Mechanism;A 9 % Spectr.
B 84 % Spectr.
cyano(2,4-dichlorophenyl)methyl ethyl carbonate

cyano(2,4-dichlorophenyl)methyl ethyl carbonate

methyl iodide
74-88-4

methyl iodide

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With water; sodium hydride Yield given. Multistep reaction;
2,4-dichlorobenzoyl chloride
89-75-8

2,4-dichlorobenzoyl chloride

methyl iodide
74-88-4

methyl iodide

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); zinc copper 1.) DMF, benzene, room temp., 1 h, then 60 deg C, 4 h, 2.) DMF, benzene, room temp., 1 h; Yield given. Multistep reaction;
2,4-dichlorobenzamide
2447-79-2

2,4-dichlorobenzamide

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride
2: diethyl ether / anschliessendes Behandeln mit wss. H2SO4
View Scheme
2,4-dichlorobenzoyl chloride
89-75-8

2,4-dichlorobenzoyl chloride

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous ammonia
2: thionyl chloride
3: diethyl ether / anschliessendes Behandeln mit wss. H2SO4
View Scheme
propargyl bromide
106-96-7

propargyl bromide

2,2',4'-trichloroacetophenone
4252-78-2

2,2',4'-trichloroacetophenone

A

1-chloro-2-(2,4-dichlorophenyl)penta-3,4-dien-2-ol
1580443-85-1

1-chloro-2-(2,4-dichlorophenyl)penta-3,4-dien-2-ol

B

C11H9Cl3O
89393-00-0

C11H9Cl3O

C

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
With indium In tetrahydrofuran; water at 20℃;
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere
2: silica gel; manganese(IV) oxide / acetonitrile / 8 h / 70 °C / Molecular sieve
View Scheme
1-Phenylethanol
98-85-1, 13323-81-4

1-Phenylethanol

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / water / 3 h / 25 °C
2: hydrogenchloride; iron sulfide; chlorine / water / 0 - 40 °C
3: sodium hydroxide / 3 h / 65 °C
4: phosphotungstic acid; dihydrogen peroxide / 5 h / 65 °C
View Scheme
(1-chloroethyl)benzene
672-65-1

(1-chloroethyl)benzene

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; iron sulfide; chlorine / water / 0 - 40 °C
2: sodium hydroxide / 3 h / 65 °C
3: phosphotungstic acid; dihydrogen peroxide / 5 h / 65 °C
View Scheme
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichlorophenacyl bromide
2631-72-3

2,4-dichlorophenacyl bromide

Conditions
ConditionsYield
With bromine In 1,4-dioxane; diethyl ether for 0.5h; Ambient temperature;100%
With copper(ll) bromide In chloroform; ethyl acetate at 40℃; for 2h;100%
With dihydrogen peroxide; bromine; sodium carbonate In dichloromethane at 20 - 40℃; Green chemistry;91.4%
4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

4-[(E)-3-(2,4-Dichloro-phenyl)-3-oxo-propenyl]-benzonitrile

4-[(E)-3-(2,4-Dichloro-phenyl)-3-oxo-propenyl]-benzonitrile

Conditions
ConditionsYield
With sodium hydroxide for 0.5h;100%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

(E)-1-(2,4-Dichloro-phenyl)-3-(4-trifluoromethyl-phenyl)-propenone

(E)-1-(2,4-Dichloro-phenyl)-3-(4-trifluoromethyl-phenyl)-propenone

Conditions
ConditionsYield
With sodium hydroxide for 0.5h;100%
4-tert-Butylbenzaldehyde
939-97-9

4-tert-Butylbenzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

3-(4-tert-butyl-phenyl)-1-(2,4-dichloro-phenyl)-propenone

3-(4-tert-butyl-phenyl)-1-(2,4-dichloro-phenyl)-propenone

Conditions
ConditionsYield
With sodium hydroxide for 1.5h;100%
4-ethylbenzylaldehyde
4748-78-1

4-ethylbenzylaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-(2,4-dichlorophenyl)-3-(4-ethylphenyl)prop-2-en-1-one

1-(2,4-dichlorophenyl)-3-(4-ethylphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 15h; Claisen-Schmidt Condensation;100%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichloro-α-methylbenzyl alcohol
1475-13-4

2,4-dichloro-α-methylbenzyl alcohol

Conditions
ConditionsYield
With sodium borohydrid In methanol; water99%
With sodium tetrahydroborate In methanol at 20℃; for 0.5h;99%
With methanol; [pentamethylcyclopentadienyl*Ir(2,2′-bpyO)(OH)][Na] at 66℃; for 12h; Inert atmosphere; Schlenk technique;94%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

(S)-1-(2',4'-dichlorophenyl)-1-ethanol
179237-92-4

(S)-1-(2',4'-dichlorophenyl)-1-ethanol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C53H73FeN2O2PS; hydrogen; lithium tert-butoxide In isopropyl alcohol at 25 - 30℃; under 22801.5 Torr; for 12h; Autoclave; enantioselective reaction;99%
With formic acid; C20H23ClIrNO3; isopropylamine In dichloromethane at 20℃; enantioselective reaction;77%
With n-hexan-2-ol; Geotrichum candidum IFO 4597 cells on BL-100 polymer In hexane at 30℃; for 24h; Reduction;71%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-(2,4-dichlorophenyl)ethan-1-one oxime
71516-67-1

1-(2,4-dichlorophenyl)ethan-1-one oxime

Conditions
ConditionsYield
With sodium hydroxide; hydroxylamine hydrochloride In methanol; water99%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 80℃;93%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
402939-95-1

1-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 15h; Claisen-Schmidt Condensation;99%
With sodium hydroxide In ethanol at 20℃;85%
With sodium hydroxide In ethanol at 0℃;83.5%
With sodium hydroxide In ethanol at 20℃; Claisen-Schmidt condensation;
With potassium hydroxide In ethanol; water Claisen-Schmidt Condensation;
diethyl cyanophosphonate
2942-58-7

diethyl cyanophosphonate

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-cyano-1-(2,4-dichlorophenyl)ethyl diethyl phosphate
1469462-83-6

1-cyano-1-(2,4-dichlorophenyl)ethyl diethyl phosphate

Conditions
ConditionsYield
With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene In toluene at 20℃; for 3h; Inert atmosphere;99%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,6-dimethoxybenzaldehyde
3392-97-0

2,6-dimethoxybenzaldehyde

(E)-1-(2,4-dichlorophenyl)-3-(2,6-dimethoxyphenyl)prop-2-en-1-one

(E)-1-(2,4-dichlorophenyl)-3-(2,6-dimethoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)ethan-1-one With sodium hydroxide In ethanol; water at 20℃; for 0.0833333h; Claisen-Schmidt Condensation;
Stage #2: 2,6-dimethoxybenzaldehyde at 20℃; Claisen-Schmidt Condensation;
99%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

C16H12Cl2O

C16H12Cl2O

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 15h; Claisen-Schmidt Condensation;99%
With potassium hydroxide In ethanol; water Claisen-Schmidt Condensation;
1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,4-bis-(2,4-dichloro-phenyl)-2-methyl-2,3-dihydro-1H-benzo[b][1,4]diazepine

2,4-bis-(2,4-dichloro-phenyl)-2-methyl-2,3-dihydro-1H-benzo[b][1,4]diazepine

Conditions
ConditionsYield
With iodine In acetonitrile at 25℃; for 0.166667h;98%
Methyl dimethoxyacetate
89-91-8

Methyl dimethoxyacetate

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-(2,4-dichlorophenyl)-4,4-dimethoxybutane-1,3-dione
857074-14-7

1-(2,4-dichlorophenyl)-4,4-dimethoxybutane-1,3-dione

Conditions
ConditionsYield
Stage #1: Methyl dimethoxyacetate; 1-(2,4-dichlorophenyl)ethan-1-one With methanol; sodium methylate In diethyl ether at 20℃; for 2h;
Stage #2: In diethyl ether for 6h; Heating / reflux;
Stage #3: In diethyl ether at 20℃;
98%
With hydrogenchloride; sodium methylate In diethyl ether at 20℃; for 2h;98%
5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde
114362-54-8

5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

C19H13Cl2N3
1421680-24-1

C19H13Cl2N3

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 0 - 80℃; for 10h;98%
1-decylindoline-2,3-dione
56932-63-9

1-decylindoline-2,3-dione

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-decyl-3-[2-(2,4-dichlorophenyl)-2-oxoethyl]-3-hydroxyindolin-2-one
1028181-37-4

1-decyl-3-[2-(2,4-dichlorophenyl)-2-oxoethyl]-3-hydroxyindolin-2-one

Conditions
ConditionsYield
With diethylamine In water; isopropyl alcohol at 20℃; for 8h;97%
6-methoxy-2H-chromene-3-carbaldehyde
57543-40-5

6-methoxy-2H-chromene-3-carbaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

(E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2H-chromen-3-yl)prop-2-en-1-one
1229681-49-5

(E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2H-chromen-3-yl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol Cooling with ice;97%
1,3-benzodioxol-5-yl(phenyl)methanol
4382-91-6, 123436-14-6

1,3-benzodioxol-5-yl(phenyl)methanol

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

3-(benzo[d][1,3]dioxol-5-yl)-1-(2,4-dichlorophenyl)-3-phenylpropan-1-one
1613458-43-7

3-(benzo[d][1,3]dioxol-5-yl)-1-(2,4-dichlorophenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trimethyl orthoformate In tetrachloromethane at 20℃; for 1h;97%
With silver hexafluoroantimonate; trimethyl orthoformate In dichloromethane for 6h; Inert atmosphere; Reflux;75%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,6-bis(2,4-dichlorophenyl)-4-(4-chlororophenyl)pyridine

2,6-bis(2,4-dichlorophenyl)-4-(4-chlororophenyl)pyridine

Conditions
ConditionsYield
With ammonium acetate In water at 130℃; for 0.1h; Kroehnke reaction; microwave irradiation;96%
With ammonium acetate for 0.1h; microwave irradiation;95%
With ammonium acetate In ethylene glycol microwave irradiation; atmospheric pressure;95%
ethylene glycol
107-21-1

ethylene glycol

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane

2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane

Conditions
ConditionsYield
With N-Bromosuccinimide at 45℃; for 24h;96%
Stage #1: 1-(2,4-dichlorophenyl)ethan-1-one With bromine In butan-1-ol at 20℃; for 2h;
Stage #2: ethylene glycol With toluene-4-sulfonic acid In butan-1-ol; benzene for 4h; Reagent/catalyst; Solvent; Reflux;
83.22%
Stage #1: 1-(2,4-dichlorophenyl)ethan-1-one With bromine In butan-1-ol at 20℃; for 1h;
Stage #2: ethylene glycol In butan-1-ol; benzene at 88 - 89℃; for 6h; Reagent/catalyst; Solvent; Temperature;
66.43%
1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

2,2-dibromo-1-(2,4-dichlorophenyl)ethanone
24123-68-0

2,2-dibromo-1-(2,4-dichlorophenyl)ethanone

Conditions
ConditionsYield
With bromine In neat (no solvent)95%
With bromine at 35 - 40℃; for 3h;51%
With bromine In tetrachloromethane
furfural
98-01-1

furfural

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

(E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)-prop-2-en-1-one

(E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)-prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 0.666667h; Claisen Schmidt condensation;95%
With potassium hydroxide In ethanol for 3h; Solvent; Temperature; Time; Reflux;92%
With Dimethyl ether In methanol at 20℃;75%
With sodium hydroxide In ethanol at 20℃; Claisen-Schmidt condensation;
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

(E)-1,3-Bis-(2,4-dichloro-phenyl)-propenone

(E)-1,3-Bis-(2,4-dichloro-phenyl)-propenone

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃;95%
N-butylisatin
4290-91-9

N-butylisatin

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1-butyl-3-[2-(2,4-dichlorophenyl)-2-oxoethyl]-3-hydroxyindolin-2-one
1028181-31-8

1-butyl-3-[2-(2,4-dichlorophenyl)-2-oxoethyl]-3-hydroxyindolin-2-one

Conditions
ConditionsYield
With diethylamine In water; isopropyl alcohol at 20℃; for 8h;95%
2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one
19738-92-2

1,3-bis(2,4-dichlorophenyl)prop-2-en-1-one

Conditions
ConditionsYield
With lithium hydroxide In ethanol; water at 21 - 23℃; for 0.00277778h; Claisen-Schmidt Condensation; Sonication;95%
With sodium hydroxide In ethanol at 0℃;68.4%
With sodium hydroxide In ethanol at 20℃; Claisen-Schmidt condensation;
formaldehyd
50-00-0

formaldehyd

(1R,2S)-(-)-norephedrine hydrochloride
3198-15-0

(1R,2S)-(-)-norephedrine hydrochloride

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

3-(2,4-dichlorophenyl)-N-((1R,2S)-1-hydroxy-1-phenyl-propan-2-yl)-3-oxopropan-1-amine hydrochloride

3-(2,4-dichlorophenyl)-N-((1R,2S)-1-hydroxy-1-phenyl-propan-2-yl)-3-oxopropan-1-amine hydrochloride

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In isopropyl alcohol at 10 - 50℃; Mannich Aminomethylation;95%
formaldehyd
50-00-0

formaldehyd

(1S,2S)-2-amino-1-phenylpropanol
492-39-7

(1S,2S)-2-amino-1-phenylpropanol

1-(2,4-dichlorophenyl)ethan-1-one
2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

3-(2,4-dichlorophenyl)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-3-oxopropan-1-amine hydrochloride

3-(2,4-dichlorophenyl)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-3-oxopropan-1-amine hydrochloride

Conditions
ConditionsYield
Stage #1: formaldehyd; (1S,2S)-2-amino-1-phenylpropanol In isopropyl alcohol at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 1-(2,4-dichlorophenyl)ethan-1-one In isopropyl alcohol at 45 - 50℃; Inert atmosphere;
Stage #3: With hydrogenchloride In ethanol; water at 10℃; Inert atmosphere; enantioselective reaction;
95%

2234-16-4Relevant articles and documents

The dehydrogenative oxidation of aryl methanols using an oxygen bridged [Cu-O-Se] bimetallic catalyst

Choudhury, Prabhupada,Behera, Pradyota Kumar,Bisoyi, Tanmayee,Sahu, Santosh Kumar,Sahu, Rashmi Ranjan,Prusty, Smruti Ranjita,Stitgen, Abigail,Scanlon, Joseph,Kar, Manoranjan,Rout, Laxmidhar

supporting information, p. 5775 - 5779 (2021/04/12)

Herein, we report a new protocol for the dehydrogenative oxidation of aryl methanols using the cheap and commercially available catalyst CuSeO3·2H2O. Oxygen-bridged [Cu-O-Se] bimetallic catalysts are not only less expensive than other catalysts used for the dehydrogenative oxidation of aryl alcohols, but they are also effective under mild conditions and at low concentrations. The title reaction proceeds with a variety of aromatic and heteroaromatic methanol examples, obtaining the corresponding carbonyls in high yields. This is the first example using an oxygen-bridged copper-based bimetallic catalyst [Cu-O-Se] for dehydrogenative benzylic oxidation. Computational DFT studies reveal simultaneous H-transfer and Cu-O bond breaking, with a transition-state barrier height of 29.3 kcal mol?1

Promoting charge separation in donor-acceptor conjugated microporous polymers: Via cyanation for the photocatalytic reductive dehalogenation of chlorides

Deng, Jiyong,Fang, Zhengjun,Lan, Donghui,Liao, Yunfeng,Liu, Qingquan,Zhang, Weijie,Zhou, Xiang

, p. 7151 - 7159 (2021/11/17)

Conjugated microporous polymers (CMPs) have emerged as promising heterogeneous photocatalysts for organic transformations owing to their structural designability and functional versatility. However, limited by the insufficient separation of the photo-generated excitons, their photocatalytic efficiency falls far short of expectations. Herein, we demonstrate a cyanation strategy to promote charge carrier separation in CMPs by selectively incorporating carbazole and cyano groups as electron-donating and electron-withdrawing units, respectively. The resulting CMPs feature π-extended donor (D)-acceptor (A) conjugation structures endowing them with distinct semiconducting properties, in which the efficient charge separation and transfer and wide visible-light absorption are facilitated. Compared to the cyano-free counterpart, the cyano-functionalized CMPs showed superior photocatalytic efficiency as exemplified by photocatalytic reductive dehalogenation of chlorides. More prominently, full recyclability of the designed CMPs as well as catalytic activity for at least ten runs without the loss of catalytic performance in photocatalytic reductive dehalogenation of chlorides demonstrated their robustness and sustainability. This journal is

Clean production method for improving reaction yield of 2, 4-dichloroacetophenone

-

Paragraph 0011-0022, (2020/04/06)

The invention relates to a clean production method for improving the reaction yield of 2, 4-dichloroacetophenone, which comprises the following steps: S1, separating and extracting m-dichlorobenzene by using chlorinated aromatic hydrocarbon waste; S2, preparing crude 2, 4-dichloroacetophenone; and S3, separating and purifying the crude 2, 4-dichloroacetophenone to obtain a dichloroacetophenone product. The method has the advantages that the optimal reaction conditions are found through the influence of the feeding ratio, the reaction temperature, the reaction time, different Lewis acids and the AlCl3 dosage on the product yield, the purity and the yield of the product are guaranteed, the purity of the product can reach 99.5% or above, and the yield of the product can reach 65% or above.

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