Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid

Base Information

• Chemical Name: Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid
• CAS No.: 1010836-49-3
• Molecular Formula: C7H12O4
• Molecular Weight: 160.2
• Hs Code.: 2932999099
• Mol file: 1010836-49-3.mol

Synonyms:4-Methoxytetrahydropyran-4-carboxylic acid;Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid;4-Methoxyoxane-4-carboxylic acid;4-METHOXY-TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID

Chemical Property of Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid

Chemical Property:

• Boiling Point: 280℃
• PKA: 3.39±0.20(Predicted)
• Flash Point: 115℃
• PSA: 55.76000
• Density: 1.19
• LogP: 0.26660

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxytetrahydropyran-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid is used in the preparation of imidazole derivatives as modulators of cannabinoid receptors CB2. 4-Methoxytetrahydropyran-4-carboxylic Acid is used in the preparation of imidazole derivatives as modulators of cannabinoid receptors CB2.

Technology Process of Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid

There total 2 articles about Tetrahydro-4-methoxy-2H-pyran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-cyano-4-methoxytetrahydropyran (155650-56-9) → 4-methoxytetrahydro-2H-pyran-4-carboxylic acid (1010836-49-3)

Guidance literature:

4-cyano-4-methoxytetrahydropyran; With water; potassium hydroxide; for 4h; Reflux;

With hydrogenchloride; water;

Reference yield:

4-methoxy-4-vinyltetrahydro-2H-pyran → 4-methoxytetrahydro-2H-pyran-4-carboxylic acid (1010836-49-3)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/cmdc.200900389

Reference yield: 47.0%

4-methoxytetrahydro-2H-pyran-4-carboxylic acid (1010836-49-3) → (4-methoxytetrahydro-2H-pyran-4-yl)methanol (1010836-50-6)

Guidance literature:

4-methoxytetrahydro-2H-pyran-4-carboxylic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Cooling with ice; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; Cooling with ice;

upstream raw materials:

4-cyano-4-methoxytetrahydropyran

Downstream raw materials:

(4-methoxytetrahydro-2H-pyran-4-yl)methanol