155650-56-9

Basic information

• Product Name: 2H-Pyran-4-carbonitrile, tetrahydro-4-methoxy-
• Synonyms: 2H-Pyran-4-carbonitrile, tetrahydro-4-methoxy-
• CAS NO: 155650-56-9
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Mol File: 155650-56-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Pyran-4-carbonitrile, tetrahydro-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-4-carbonitrile, tetrahydro-4-methoxy-(155650-56-9)
• EPA Substance Registry System: 2H-Pyran-4-carbonitrile, tetrahydro-4-methoxy-(155650-56-9)

Safety Data

• Hazardous Substances Data: 155650-56-9(Hazardous Substances Data)

Upstream product

• 28218-71-5 4,4-dimethoxytetrahydro-4H-pyran 
• 119072-55-8 tert-butylisonitrile 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Downstream Products

• 1269755-10-3 (4-methoxytetrahydro-2H-pyran-4-yl)methanamine 
• 1010836-49-3 4-methoxytetrahydro-2H-pyran-4-carboxylic acid 
• 1270077-00-3 6-(benzyloxy)-3-fluoro-N-((4-methoxytetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine 
• 175982-76-0 4-methoxytetrahydro-2H-pyran-4-carbaldehyde 
• 175982-78-2 1-(4-Methoxy-tetrahydro-pyran-4-yl)-ethanone 

Relevant articles and documents

Efficient preparation of 4-methoxy-5,6-dihydro-2H-pyran

We report the efficient synthesis of 4-methoxy-5,6-dihydro-2H-pyran (MDHP) via the TiCl4 driven elimination of MeOH from 4,4-dimethoxytetrahydropyran. The previous difficulty of preparing MDHP restricted the wider use of 4-methoxytetrahydropyran-4-yl (MTHP) acyclic acetals, which have desirable protecting group properties when compared to more commonly used MOM- and THP-acetals. The behaviour of the elimination on related acetals is also examined.

3-(AMINOARYL)-PYRIDINE COMPOUNDS

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.

N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.