5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid

Base Information

Chemical Name:5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid
CAS No.:153894-33-8
Molecular Formula:C13H11NO2S
Molecular Weight:245.29694
Hs Code.:2934999090
DSSTox Substance ID:DTXSID90566069
Wikidata:Q72466286
Mol file:153894-33-8.mol

Synonyms:153894-33-8;5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid;5,6-Dihydro-4H-thieno[3,2-d][1]benzazepine-2-carboxylic acid;MFCD18252314;5,6-Dihydro-4H-1-thia-6-aza-benzo[e]azulene-2-carboxylic acid;SCHEMBL11910393;DTXSID90566069;AKOS016000537;DS-5557;SY103152;CS-0089742;F11822;A903810;5,6-DIHYDRO-4H-BENZO[B]THIENO[2,3-D]AZEPINE-2-CARBOXYLICACID

Suppliers and Price of 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicAcid
50mg
$ 225.00

TRC
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicAcid
25mg
$ 130.00

TRC
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicAcid
10mg
$ 80.00

Crysdot
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 95+%
250mg
$ 473.00

Crysdot
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 95+%
1g
$ 1184.00

Crysdot
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 95+%
100mg
$ 295.00

American Custom Chemicals Corporation
5,6-DIHYDRO-4H-BENZO[B]THIENO[2,3-D]AZEPINE-2-CARBOXYLIC ACID 95.00%
5MG
$ 500.90

Ambeed
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 97%
100mg
$ 230.00

Ambeed
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 97%
1g
$ 857.00

Ambeed
5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicacid 97%
250mg
$ 857.00

Total 14 raw suppliers

Chemical Property of 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid

Chemical Property:

Boiling Point:531.6±38.0 °C(Predicted)
PKA:3.41±0.20(Predicted)
PSA：77.57000
Density:1.348
LogP:3.21930
Storage Temp.:2-8°C(protect from light)
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:245.05104977
Heavy Atom Count:17
Complexity:310

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC2=CC=CC=C2C3=C1C=C(S3)C(=O)O
Uses 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic Acid is an intermediate used to prepare benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors.

Technology Process of 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid

There total 9 articles about 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 153894-28-1
2-carbethoxy-4,5,6-trihydro-6-tosylthiopheno<3,2-d><1>benzazepin

: 153894-33-8
2-carboxy-4,5,6-trihydrothiopheno<3,2-d><1>benzazepine

Guidance literature:: With sulfuric acid; at 0 - 70 ℃; for 2h;
DOI:10.1039/d0ob00564a

Reference yield:

: 24310-36-9
1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 153894-33-8
2-carboxy-4,5,6-trihydrothiopheno<3,2-d><1>benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / phosphoryl chloride / 2 h / 0 - 80 °C

2: 86 percent / EtONa / ethanol / a) RT, overnight, b) reflux, 0.5 h

3: 45 percent / 50percent aq. H₂SO₄, AcOH / 6 h / Heating

With sulfuric acid; sodium ethanolate; acetic acid; trichlorophosphate; In ethanol;

Reference yield:

: 153894-28-1
2-carbethoxy-4,5,6-trihydro-6-tosylthiopheno<3,2-d><1>benzazepin

: 1261276-90-7
C₁₃H₁₀BrNO₂S

: 153894-33-8
2-carboxy-4,5,6-trihydrothiopheno<3,2-d><1>benzazepine

Guidance literature:: 2-carbethoxy-4,5,6-trihydro-6-tosylthiopheno<3,2-d><1>benzazepin; With hydrogen bromide; acetic acid; Reflux;

With sulfuric acid; water; for 6h; Reflux;