1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Base Information Edit

Chemical Name:1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
CAS No.:24310-36-9
Molecular Formula:C17H17NO3S
Molecular Weight:315.393
Hs Code.:2933990090
NSC Number:105655
DSSTox Substance ID:DTXSID80295831
Nikkaji Number:J108.413E
Wikidata:Q72509274
ChEMBL ID:CHEMBL4959086
Mol file:24310-36-9.mol

Synonyms:24310-36-9;1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;1-tosyl-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-;1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one;MFCD00795994;1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE;1,2,3,4-TETRAHYDRO-1-[(4-METHYLPHENYL)SULFONYL]-5H-1-BENZAZEPIN-5-ONE;1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one;NSC105655;SCHEMBL1495922;CHEMBL4959086;AMY1908;DTXSID80295831;TQP0901;5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(p-tolylsulfonyl)-;AKOS015842544;AB07154;AE-0248;CCG-277880;CS-W012036;NSC-105655;AC-25909;BP-30012;SY030925;FT-0681896;J-505162;1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1-tosyl-3,4-dihydro-1H-benzo[b]azepine-5(2H)-one;1-tosyl-2,3,4,5-tetrahydro-1-H-1 -benzazepin-5-one;5H-1-Benzazepin-5-one,2,3,4-tetrahydro-1-(p-tolylsulfonyl)-;1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-5-one;1-(p-toluenesulfonyl)-5-oxo-2,3,4,5-tetrahydro-1H-benzazepine;(+/-)1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one;1-(4-Methylbenzene-1-sulfonyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1-[(4-Methylbenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one #;5H-1-Benzazepin-5-one,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-

Suppliers and Price of 1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
25mg
$ 55.00

SynQuest Laboratories
1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
1 g
$ 381.00

SynQuest Laboratories
1-(Toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
500 mg
$ 272.00

Sigma-Aldrich
1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE Aldrich
25mg
$ 144.00

Matrix Scientific
1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 95+%
5g
$ 360.00

Matrix Scientific
1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 95+%
1g
$ 142.00

Chemenu
1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 95%
5g
$ 295.00

Chemenu
1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 95%
1g
$ 129.00

BroadPharm
1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 98%
1 G
$ 165.00

BroadPharm
1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 98%
500 MG
$ 120.00

Total 37 raw suppliers

Chemical Property of 1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:126 °C(Solv: methanol (67-56-1))
Refractive Index:1.614
Boiling Point:489.668 ºC at 760 mmHg
PKA:-3?+-.0.20(Predicted)
Flash Point:249.9 ºC
PSA：62.83000
Density:1.287 g/cm3
LogP:4.31260
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:315.09291458
Heavy Atom Count:22
Complexity:503

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2CCCC(=O)C3=CC=CC=C32
Uses 1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one is an intermediate used to prepare nonpeptide vasopressin V2 receptor antagonist tetrahydro-1H-benzazepines. It is also used to synthesize 4''-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanilide derivatives as non-peptide arginine vasopressin antagonists for both V1A and V2 receptors.

Technology Process of 1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

There total 23 articles about 1-Tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%