spiro[2.5]octan-5,7-dione

Base Information

• Chemical Name: spiro[2.5]octan-5,7-dione
• CAS No.: 893411-52-4
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.166
• Hs Code.: 2914299000
• Mol file: 893411-52-4.mol

Synonyms:QC-9561;

Chemical Property of spiro[2.5]octan-5,7-dione

Chemical Property:

• Boiling Point: 285.7±23.0 °C(Predicted)
• PKA: 9.50±0.20(Predicted)
• PSA: 34.14000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 1.08870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

spiro[2.5]octane-5,7-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiro[2.5]octan-5,7-dione

There total 14 articles about spiro[2.5]octan-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

[1-(2-oxo-propyl)-cyclopropyl]-acetic acid methyl ester (1554535-04-4) → spiro[2.5]octane-5,7-dione (893411-52-4)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

Reference yield: 54.0%

cyclopropylidenepropanone (62266-37-9) + malonic acid dimethyl ester (108-59-8) → spiro[2.5]octane-5,7-dione (893411-52-4)

Guidance literature:

cyclopropylidenepropanone; malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; toluene; benzene; for 4h; Reflux;

With water; potassium hydroxide; In tetrahydrofuran; toluene; benzene; for 1h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; toluene; benzene; pH=1;

Reference yield: 44.0%

diethyl 5,7-dioxospiro[2.5]octane-4,6-dicarboxylate → spiro[2.5]octane-5,7-dione (893411-52-4)

Guidance literature:

diethyl 5,7-dioxospiro[2.5]octane-4,6-dicarboxylate; With potassium hydroxide; In water; for 5h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; for 1h; pH=2.5 - 3.0; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.09.132

upstream raw materials:

cyclopropylidenepropanone

malonic acid dimethyl ester

(1-methoxycarbonylmethyl-cyclopropyl)-acetic acid

(1-chlorocarbonylmethyl-cyclopropyl)-acetic acid methyl ester

Downstream raw materials:

4'-cyclohexyl-2'-cyclopentyl-3'-[4-(trifluoromethyl)benzoyl]-4',8'-dihydro-1'H-spiro[cyclopropan-1,7'-quinolin]-5'(6'H)-one

C₁₇H₁₈N₂O₂

C₁₇H₁₇BrN₂O₂

2'-((4-chlorophenyl)amino)-6',8'-dihydro-5'H-spiro[cyclopropane-1,7'-quinazolin]-5'-one

Refernces

• 1、 -. "NOVEL PROCESS FOR PREPARATION OF SPIRO[2.5]OCTANE-5,7-DIONE AND SPIRO[3.5]NONANE-6,8-DIONE". Page/Page column 20. . Retrieved 2016/04/20.
• 2、 -. "Process for preparing spiro[2.5]octane-5,7-dione". . . Retrieved 2014/02/16.