2-Amino-3-chlorobenzaldehyde

Base Information

• Chemical Name: 2-Amino-3-chlorobenzaldehyde
• CAS No.: 397322-82-6
• Molecular Formula: C7H6ClNO
• Molecular Weight: 155.584
• Hs Code.: 2922399090
• Mol file: 397322-82-6.mol

Synonyms:2-Amino-3-chlorobenzaldehyde; benzaldehyde, 2-amino-3-chloro-

Chemical Property of 2-Amino-3-chlorobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Melting Point: 30-31 °C
• Boiling Point: 264.3°C at 760 mmHg
• PKA: -1.59±0.10(Predicted)
• Flash Point: 113.645°C
• PSA: 43.09000
• Density: 1.349g/cm³
• LogP: 2.31590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-chlorobenzaldehyde

There total 4 articles about 2-Amino-3-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2-amino-3-chlorophenyl)methanol (61487-25-0) → 2-amino-3-chlorophenylformaldehyde (397322-82-6)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02714

Reference yield: 50.0%

2-amino-3-chlorobenzonitrile (53312-77-9) → 2-amino-3-chlorophenylformaldehyde (397322-82-6)

Guidance literature:

2-amino-3-chlorobenzonitrile; With diisobutylaluminium hydride; In dichloromethane; toluene; at 20 ℃; for 24h;

With sodium hydroxide; In dichloromethane; toluene; at 20 ℃; for 0.25h; Further stages.;

DOI:10.1021/ja077473r

Reference yield:

3-chloro-2-nitrobenzaldehyde (22233-52-9) → 2-amino-3-chlorophenylformaldehyde (397322-82-6)

Guidance literature:

With hydrogenchloride; iron; acetic acid; In ethanol; at 70 ℃;

DOI:10.1016/j.bmcl.2013.10.008

upstream raw materials:

2-amino-3-chlorobenzonitrile

(2-amino-3-chlorophenyl)methanol

3-chloro-2-nitrobenzaldehyde

Downstream raw materials:

2,8-dichloroquinazoline