2,8-Dichloroquinazoline

Base Information

• Chemical Name: 2,8-Dichloroquinazoline
• CAS No.: 67092-20-0
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.04
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90497142
• Wikidata: Q82346537
• Mol file: 67092-20-0.mol

Synonyms:2,8-Dichloroquinazoline;67092-20-0;SCHEMBL2917596;2 pound not8-Dichloroquinazoline;DTXSID90497142;MFCD13193682;AKOS016004822;DS-2478;FT-0732568;A867337

Chemical Property of 2,8-Dichloroquinazoline

Chemical Property:

• Vapor Pressure: 0.271mmHg at 25°C
• Refractive Index: 1.671
• Boiling Point: 210.976°C at 760 mmHg
• Flash Point: 101.202°C
• PSA: 25.78000
• Density: 1.487g/cm³
• LogP: 2.93660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 197.9751535
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

2,8-Dichloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=CN=C(N=C2C(=C1)Cl)Cl

Technology Process of 2,8-Dichloroquinazoline

There total 6 articles about 2,8-Dichloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,8-dichloroquinazoline-4-amine (1107694-84-7) → 2,8-dichloroquinazoline (67092-20-0)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; at 60 ℃; for 4h;

Reference yield:

8-Chlor-2-oxo-1,2-dihydrochinazolin (60610-15-3) → 2,8-dichloroquinazoline (67092-20-0)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield:

3-chloro-2-nitrobenzaldehyde (22233-52-9) → 2,8-dichloroquinazoline (67092-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; iron; hydrogenchloride / ethanol / 70 °C

2: 180 °C

3: trichlorophosphate / 110 °C

With hydrogenchloride; iron; acetic acid; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2013.10.008

upstream raw materials:

2,8-dichloroquinazoline-4-amine

3-chloro-2-nitrobenzaldehyde

2-amino-3-chlorophenylformaldehyde

8-Chlor-2-oxo-1,2-dihydrochinazolin

Downstream raw materials:

N-(3-(8-chloroquinazolin-2-ylamino)phenyl)acetamide