1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine

Base Information

Chemical Name:1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine
CAS No.:149401-02-5
Molecular Formula:C13H17F3N2
Molecular Weight:258.287
Hs Code.:
DSSTox Substance ID:DTXSID70589418
Wikidata:Q82482780
Mol file:149401-02-5.mol

Synonyms:149401-02-5;1-(4-(Trifluoromethyl)benzyl)piperidin-4-amine;1-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDIN-4-AMINE;1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-amine;1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine;1-{[4-(trifluoromethyl)phenyl]methyl}piperidin-4-amine;SCHEMBL6941820;DTXSID70589418;IONRLOMCVXWXIJ-UHFFFAOYSA-N;AKOS005171466;DB-013776;A1-39421;4-Piperidinamine, 1-[[4-(trifluoromethyl)phenyl]methyl]-

Suppliers and Price of 1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
1-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDIN-4-AMINE 95%
1 g
$ 550.00

Chemenu
1-[4-(trifluoromethyl)benzyl]piperidin-4-amine 95%
1g
$ 408.00

American Custom Chemicals Corporation
1-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDIN-4-AMINE 95.00%
0.5G
$ 682.00

Alichem
1-(4-(Trifluoromethyl)benzyl)piperidin-4-amine
1g
$ 387.20

Total 5 raw suppliers

Chemical Property of 1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine

Chemical Property:

Boiling Point:293.9±40.0 °C(Predicted)
PKA:10.09±0.20(Predicted)
PSA：29.26000
Density:1.190±0.06 g/cm3(Predicted)
LogP:3.26670
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:258.13438304
Heavy Atom Count:18
Complexity:252

Purity/Quality:

99.3% ^*data from raw suppliers

1-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDIN-4-AMINE 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1N)CC2=CC=C(C=C2)C(F)(F)F

Technology Process of 1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine

There total 7 articles about 1-[4-(Trifluoromethyl)benzyl]piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: tert-butyl N-[1-[[4-(trifluoromethyl)phenyl]methyl]-4-piperidyl]carbamate

: 149401-02-5
4-Amino-1-(4-trifluoromethylbenzyl)piperidine

Guidance literature:: With hydrogenchloride; In methanol; water; at 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 380424-34-0
1-(4-trifluoromethylbenzyl)piperidine-4-carboxamide

: 149401-02-5
4-Amino-1-(4-trifluoromethylbenzyl)piperidine

Guidance literature:: With bis-[(trifluoroacetoxy)iodo]benzene; In water; acetonitrile; at 65 ℃;
DOI:10.1081/NCN-100002493

Reference yield:

: 1057266-16-6
1-(4-trifluoromethylbenzyl)-4-piperidone oxime

: 149401-02-5
4-Amino-1-(4-trifluoromethylbenzyl)piperidine

Guidance literature:: 1-(4-trifluoromethylbenzyl)-4-piperidone oxime; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; Product distribution / selectivity;