1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine

Base Information

• Chemical Name: 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine
• CAS No.: 149401-02-5
• Molecular Formula: C13H17F3N2
• Molecular Weight: 258.287
• Mol file: 149401-02-5.mol

Synonyms:1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine

Chemical Property of 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine

Chemical Property:

• Boiling Point: 293.9±40.0 °C(Predicted)
• PKA: 10.09±0.20(Predicted)
• PSA: 29.26000
• Density: 1.190±0.06 g/cm3(Predicted)
• LogP: 3.26670
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

1-[4-(TRIFLUOROMETHYL)BENZYL]PIPERIDIN-4-AMINE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine

There total 7 articles about 1-(4-Trifluoromethyl-benzyl)-piperidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

tert-butyl N-[1-[[4-(trifluoromethyl)phenyl]methyl]-4-piperidyl]carbamate → 4-Amino-1-(4-trifluoromethylbenzyl)piperidine (149401-02-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 1h; Inert atmosphere;

Reference yield:

1-(4-trifluoromethylbenzyl)piperidine-4-carboxamide (380424-34-0) → 4-Amino-1-(4-trifluoromethylbenzyl)piperidine (149401-02-5)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In water; acetonitrile; at 65 ℃;

DOI:10.1081/NCN-100002493

Reference yield:

1-(4-trifluoromethylbenzyl)-4-piperidone oxime (1057266-16-6) → 4-Amino-1-(4-trifluoromethylbenzyl)piperidine (149401-02-5)

Guidance literature:

1-(4-trifluoromethylbenzyl)-4-piperidone oxime; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; Product distribution / selectivity;

upstream raw materials:

1-(4-trifluoromethylbenzyl)piperidine-4-carboxamide

4-trifluoromethylbenzyl chloride

1-(4-trifluoromethylbenzyl)-4-piperidone oxime

4-carboxamidopiperidine

Downstream raw materials:

2-chloro-6-[4-(1-(4-trifluoromethylbenzyl))piperidinylamino]-9-cyclopentylpurine

Refernces

• 1、 Shidore, Mahesh,Machhi, Jatin,Shingala, Kaushik,Murumkar, Prashant,Sharma, Mayank Kumar,Agrawal, Neetesh,Tripathi, Ashutosh,Parikh, Zalak,Pillai, Prakash,Yadav, Mange Ram. "Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation". . p. 5823 - 5846. Retrieved 2016/07/06.
• 2、 Shum,Peet,Weintraub,Le,Zhao,Barbone,Cashman,Tsay,Dwyer,Loos,Powers,Kropp,Wright,Bitonti,Dumont,Borcherding. "The design and synthesis of purine inhibitors of CDK2. III". . p. 1067 - 1078. Retrieved 2007/10/03.