TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE
• CAS No.: 934536-10-4
• Molecular Formula: C10H19FN2O2
• Molecular Weight: 218.271
• Hs Code.: 2933399090
• Mol file: 934536-10-4.mol

Synonyms:TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE;4-AMino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-aMino-3-fluoro-, 1,1-diMethylethyl ester;1-Boc-3-fluoro-4-aMinopiperidine;4-AMino-1-Boc-3-fluoropiperidine;1-(tert-Butyloxycarbonyl)-3-fluoro-4-aminopiperidine

Chemical Property of TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 285.6±40.0 °C(Predicted)
• PKA: 8.88±0.40(Predicted)
• PSA: 55.56000
• Density: 1.11±0.1 g/cm3(Predicted)
• LogP: 1.93080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(tert-Butyloxycarbonyl)-3-Fluoro-4-aminopiperidine is a reactant in the preparation of pharmaceutical compounds which are antagonists of CGRP (Calcitonin gene-related peptide) receptors and useful in the treatment of migraine.

Technology Process of TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE

There total 9 articles about TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → (trans)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (934536-10-4,577691-56-6)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 75.0%

tert-butyl 4-azido-3-fluoropiperidine-1-carboxylate → (trans)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (934536-10-4,577691-56-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 48h;

Reference yield: 64.0%

pyridine (110-86-1) + 1-tert-butyl-3-fluoro-4-aminopiperidine → (trans)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate (934536-10-4,577691-56-6)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

upstream raw materials:

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

4-Benzyloxycarbonylamino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-fluoro-4-[[4-[(imidazo[1,2-a]pyridine-6-carbonylamino)methyl]phenyl]sulfonylamino]piperidine-1-carboxylate

tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

(3R,4R)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

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