(R)-1,2,3,4-tetrahydro-2-naphthylamine

Base Information

• Chemical Name: (R)-1,2,3,4-tetrahydro-2-naphthylamine
• CAS No.: 2217-42-7
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Mol file: 2217-42-7.mol

Synonyms:

Chemical Property of (R)-1,2,3,4-tetrahydro-2-naphthylamine

Chemical Property:

• PSA: 26.02000
• LogP: 2.20290

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1,2,3,4-tetrahydro-2-naphthylamine

There total 27 articles about (R)-1,2,3,4-tetrahydro-2-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-2-(1,2,3,4-Tetrahydro-naphthalen-2-yl)-isoindole-1,3-dione (61523-37-3) → (2R)-2-amino-1,2,3,4-tetrahydronaphthalene (2217-42-7,2954-50-9,21880-87-5,21966-60-9)

Guidance literature:

With hydrazine; In ethanol;

DOI:10.1016/S0040-4039(00)00327-0

Reference yield: 87.0%

benzyl(1,2,3,4-tetrahydronaphthalen-2-yl)amine (1246472-55-8) → (2S)-(1,2,3,4-tetrahydronaphthalen-2-yl)amine (2217-42-7,2954-50-9,21880-87-5,21966-60-9)

Guidance literature:

With palladium on carbon; hydrogen; In ethanol; at 45 ℃; for 2h; under 3750.38 Torr; Autoclave;

DOI:10.1016/j.tetasy.2010.03.027

Reference yield: 83.0%

(2R)-2-azido-1,2,3,4-tetrahydronaphthalene (460740-21-0) → (2R)-2-amino-1,2,3,4-tetrahydronaphthalene (2217-42-7,2954-50-9,21880-87-5,21966-60-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0957-4166(02)00098-8

upstream raw materials:

(R)-2-(1,2,3,4-Tetrahydro-naphthalen-2-yl)-isoindole-1,3-dione

(2R)-2-azido-1,2,3,4-tetrahydronaphthalene

(1R,2S)-1,2-dihydronaphthalene-1,2-diol

(1R,2S)-1,2,3,4-tetrahydronaphthalene-1,2-diol

Downstream raw materials:

N-[-(R)-1,2,3,4-tetrahydronaphth-2-yl]-(S)-2-hydroxy-3-(2-allylphenoxy)propanamine

Refernces

• 1、 -. "(R)- SELECTIVE AMINATION". Paragraph 0120; 0121; 0122. . Retrieved 2016/03/22.
• 2、 Fesko, Kateryna,Steiner, Kerstin,Breinbauer, Rolf,Schwab, Helmut,Schuermann, Martin,Strohmeier, Gernot A.. "Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines". . p. 103 - 110. Retrieved 2013/10/22.