4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine

Base Information

• Chemical Name: 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine
• CAS No.: 930093-72-4
• Molecular Formula: C11H10ClN3O
• Molecular Weight: 235.673
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID90704843
• Wikidata: Q72454289
• Mol file: 930093-72-4.mol

Synonyms:930093-72-4;4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine;4-Chloro-5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidine;4-chloro-5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidine;4-(2-methylpyridin-3-yloxy)-6-chloro-5-methylpyrimidine;4-Chloro-5-methyl-6-[(2-methylpyridin-3-yl)oxy]pyrimidine;SCHEMBL2403976;DTXSID90704843;SLKKQWWYTQOOHM-UHFFFAOYSA-N;MFCD12756519;AKOS016011758;SB60636;AS-69941;BP-11959;CS-0061208;FT-0735701;W17572;4-chloro-5-methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidine;4-Chloro-5-methyl-6-[(2-methyl-3-pyridyl)oxy]pyrimidine

Chemical Property of 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine

Chemical Property:

• Boiling Point: 342.7±42.0 °C(Predicted)
• PKA: 5.15±0.10(Predicted)
• PSA: 47.90000
• Density: 1.279
• LogP: 2.93410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 235.0512396
• Heavy Atom Count: 16
• Complexity: 229

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Methylpyridin-3-yloxy)-6-chloro-5-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(N=CN=C1Cl)OC2=C(N=CC=C2)C

Technology Process of 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine

There total 1 articles about 4-Chloro-5-methyl-6-((2-methylpyridin-3-yl)oxy)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

2-methyl-3-pyridinol (1121-25-1,55780-69-3) + 4,6-dichloro-5-methylpyrimidine (4316-97-6) → 4-chloro-5-methyl-6-[(2-methylpyridin-3-yl)oxy]pyrimidine (930093-72-4)

Guidance literature:

2-methyl-3-pyridinol; 4,6-dichloro-5-methylpyrimidine; In ISOPROPYLAMIDE; at -8 ℃; for 1h;

With potassium carbonate; In ISOPROPYLAMIDE; at -7.2 - 20 ℃; for 5h;

Reference yield: 99.0%

4-chloro-5-methyl-6-[(2-methylpyridin-3-yl)oxy]pyrimidine (930093-72-4) + N-benzyl-3-azabicyclo[3.2.1]octan-8α-ol (521944-15-0) → C25H28N4O2 (1147553-19-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield: 58.0%

(cis)-3-(4-fluoro-phenoxy)-8-aza-bicyclo[3.2.1]octane (653600-07-8) + 4-chloro-5-methyl-6-[(2-methylpyridin-3-yl)oxy]pyrimidine (930093-72-4) → C24H25FN4O2 (1233322-62-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 180 ℃; for 1h; microwave;

upstream raw materials:

2-methyl-3-pyridinol

4,6-dichloro-5-methylpyrimidine

Downstream raw materials:

C₂₅H₂₈N₄O₂

C₂₄H₂₅FN₄O₂

C₂₄H₂₅FN₄O₄S

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