Chemical Property of ANISODAMINE
Chemical Property:
- Appearance/Colour:No Data Available
- Melting Point:No Data Available
- Boiling Point:No Data Available
- PKA:14.12±0.10(Predicted)
- PSA：70.00000
- Density:1.27
- LogP:0.83960
- Storage Temp.:Sealed in dry,Room Temperature
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:0.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:305.16270821
- Heavy Atom Count:22
- Complexity:396
- Purity/Quality:
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99% *data from raw suppliers
Racanisodamine 98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1C2CC(CC1C(C2)O)OC(=O)C(CO)C3=CC=CC=C3
- Isomeric SMILES:CN1[C@H]2C[C@H](CC1C[C@@H]2O)OC(=O)[C@H](CO)C3=CC=CC=C3
- Recent ClinicalTrials:FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients
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Description
Amisodamine is a kind of alkaloid which is mainly living in anisodus tanguticus,
which is a M receptor just like Atropine. It is a kind of traditional Chinese medicine
which comes from the “National assembly of Chinese Herbal medicine”, and it is
the alias of zangjia registered in “Chines herbal medicine summary of shan gan ning
qing”. It is a perennial root herb that lives in the bottom slope in the eastern Tibet,
Qinghai Province, the Southern GanSu Province, the western SiChuan Province, the
northwestward YunNan Province. Since the sources is scare, racemic form of raceanisodamine
is the main drug in clinic. Anisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively. Anisodamine also has antioxidant effects that may protect against free radical-induced cellular damage. Anisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.
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Physical properties
Appearance: raceanisodamine is a kind of white crystal and crystalline powder. It is
odorless and bitter to the taste. Solubility: it is easy dissolubility in hydrochloric acid
and ethyl alcohol and is soluble in water. Melting point: it’s melting point is from
103 to 113?°C.?The weld spacing is within 6°. Specific optical rotation: ?9° to +11°.
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Uses
anticholinergic, antispasmodic Tropic Acid 6-Hydroxy-3-tropanyl Ester is a Hycosamine (H674300) derivative, which is a natural compound with inhibitory activity against cholinesterases.
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Indications
Anisodamine is a kind of anticholinergic agent. The tablet and injection form are
mainly used to relieve smooth muscle spasm, biliary spasm and AOIP in clinical
practice. The eye drop is used to treat teenage pseudomyopia; raceanisodamine concomitant
with other drugs to treat cluster headache syndrome, renal colic, infantile
diarrhea, infantile jaundice hepatitis, infantile purpura, bronchopneumonia, etc.
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Clinical Use
Anisodamine is a new drug developed by Chinese scientists. It has been widely put
into use in clinical practice such as slow reflow phenomenon of ST-elevation acute
myocardial infarction patients with percutaneous coronary intervention, infusion leakage
, neonatal sclerosis. At present, it is mainly used to dilate vessels, remove vasospasm,
improve blood circulation, increase tolerance of ischemia hypoxia and reduce
the probability of the surrounding tissue necrosis
