Chemical Property of [(4R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] 3-hydroxy-2-phenylpropanoate
Chemical Property:
- Appearance/Colour:White crystalline powder
- Melting Point:59 °C
- Refractive Index:1.5022 (estimate)
- Boiling Point:460.313 °C at 760 mmHg
- PKA:7.55-7.81(at 25℃)
- Flash Point:232.189 °C
- PSA：62.30000
- Density:1.313 g/cm3
- LogP:0.85600
- Storage Temp.:-20°C
- Solubility.:Soluble in water, freely soluble in ethanol (96 per cent).
- Water Solubility.:95g/L(15 oC)
- XLogP3:0.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:303.14705815
- Heavy Atom Count:22
- Complexity:418
- Purity/Quality:
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≥98% *data from raw suppliers
Scopolamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+
- Statements:
26/27/28
- Safety Statements:
25-45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4
- Isomeric SMILES:CN1C2CC(CC1C3[C@@H]2O3)OC(=O)C(CO)C4=CC=CC=C4
- Recent ClinicalTrials:PET and MRI Imaging With Scopolamine at the Muscarinic M1 Receptor
- Recent EU Clinical Trials:Evaluation of the long-term efficacy of the injection of botulinum toxin A into the salivary glands versus scopolamine patches in the treatment of drooling in children over 4 years old with cerebral palsy (TOXSIALO-TRIAL)
- Recent NIPH Clinical Trials:Study of the upper gastrointestinal tract peristalsis inhibitory effect of acupuncture in endoscopic submucosal dissection for early gastric cancer: A randomized controlled trial.
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Description
Scopolamine is a type of alkaloid that exists in a variety of Solanaceae plants such
as Scopolia japonica, Datura metel L., and so on. It is the main active ingredient in
these plants.Apart from scopolamine, several other chemical ingredients also exist in Scopolia
japonica, including hyoscyamine, anisodamine, anisodine, and so on. Hyoscyamine
is an inhibitor of parasympathetic nerve, with the analgesic and antispasmodic functions, especially for sciatica, sometimes for the treatment of epilepsy, seasickness,
etc., and its pharmacological effects are similar to atropine. However, its clinical
application is less because of its toxicity. The clinical applications of anisodamine
are treating infectious toxic shock, vascular disorders, various neuralgia, smooth
muscle spasms, vertigo, fundus disorders and sudden deafness, and other diseases.
It has definite curative effect and is widely used in clinical in China. Its synthetic
product is called “654-2,” which now still is an effective drug to treat infectious
shock and other vascular diseases. While anisodine is used to treat vascular headache, retinal vasospasm, ischemic optic neuritis, cerebrovascular disease, acute
paralysis, central dysfunction caused by carbon monoxide poisoning, tremor, paralysis, bronchial asthma, motion sickness, organophosphorus pesticide poisoning,
and so on .
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Physical properties
Appearance: a kind of viscous liquid, brown color. Solubility: soluble in ethanol,
ethyl ether, chloroform, acetone, and water, very soluble in hot water, slightly soluble in benzene and petroleum ether, and also soluble in cold water. It can generate
various crystals with multiple inorganic or organic acids. Melting point: 59±1.0?°C
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Uses
Scopolamine is used for practically the same indications as atropine, but it should be noted
that it has a sedative effect on motor activity, and it is recommended for the treatment of
Parkinsonian symptoms. cholinergic (ophthalmic).
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Clinical Use
The commercially available transdermal system of scopolaminecomprises an outer layer of polymer film and a drug reservoircontaining scopolamine, polyisobutylene, and mineral oil, which is interfaced with a microporous membrane tocontrol diffusion of the drug. In this dosage form, scopolamineis effective in preventing motion sickness. The actionis believed to be on the cortex or the vestibular apparatus.Whereas atropine stimulates the CNS, causing restlessnessand talkativeness, scopolamine usually acts as a CNSdepressant.
