6-Chloro-5-fluoropicolinic acid

Base Information

Chemical Name:6-Chloro-5-fluoropicolinic acid
CAS No.:860296-24-8
Molecular Formula:C6H3ClFNO2
Molecular Weight:175.547
Hs Code.:2933399090
European Community (EC) Number:838-648-9
DSSTox Substance ID:DTXSID10465020
Wikidata:Q82290658
Mol file:860296-24-8.mol

Synonyms:6-Chloro-5-fluoropicolinic acid;860296-24-8;6-chloro-5-fluoropyridine-2-carboxylic acid;MFCD13185819;2-CHLORO-3-FLUOROPYRIDINE-6-CARBOXYLIC ACID;6-chloro-5-fluoro-pyridine-2-carboxylic Acid;2-chloro-3-fluoropyridine-6-carboxylicacid;6-Chloro-5-fluoropicolinicacid;SCHEMBL2595331;DTXSID10465020;JHFKXHUKNYFWJM-UHFFFAOYSA-N;AKOS005257857;AB66795;AM62411;CS-W007835;DS-14300;SY038170;6-chloro-5-fluoro-2-pyridinecarboxylic acid;FT-0684556;EN300-84298;A863342;AU-004/43508172;6-Chloro-5-fluoropyridine-2-carboxylic acid, AldrichCPR;Z1250208606

Suppliers and Price of 6-Chloro-5-fluoropicolinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-5-fluoropicolinicacid
250mg
$ 55.00

Sigma-Aldrich
6-Chloro-5-fluoropyridine-2-carboxylic acid AldrichCPR
1g
$ 201.00

Matrix Scientific
6-Chloro-5-fluoropyridine-2-carboxylic acid 95%
5g
$ 168.00

Matrix Scientific
6-Chloro-5-fluoropyridine-2-carboxylic acid 95%
1g
$ 42.00

Crysdot
6-Chloro-5-fluoropicolinicacid 97%
25g
$ 589.00

Crysdot
6-Chloro-5-fluoropicolinicacid 97%
100g
$ 2111.00

Crysdot
6-Chloro-5-fluoropicolinicacid 97%
10g
$ 292.00

Chemenu
6-Chloro-5-fluoropyridine-2-carboxylic acid 97%
25g
$ 557.00

Chemenu
6-Chloro-5-fluoropyridine-2-carboxylic acid 97%
10g
$ 276.00

Apolloscientific
6-Chloro-5-fluoropicolinicacid 97%
25g
$ 561.00

Total 21 raw suppliers

Chemical Property of 6-Chloro-5-fluoropicolinic acid

Chemical Property:

Melting Point:193-195 °C(Solv: heptane (142-82-5))
Boiling Point:310.3±37.0 °C(Predicted)
PKA:3.21±0.10(Predicted)
PSA：50.19000
Density:1.576±0.06 g/cm3(Predicted)
LogP:1.57230
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Water Solubility.:Slightly soluble in water.
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:174.9836342
Heavy Atom Count:11
Complexity:167

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-5-fluoropicolinicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC(=C1F)Cl)C(=O)O
Uses It is an important intermediate for pharmaceutical.

Technology Process of 6-Chloro-5-fluoropicolinic acid

There total 9 articles about 6-Chloro-5-fluoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 860296-23-7
6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid

: 860296-24-8
6-chloro-5-fluoro-pyridine-2-carboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In diethyl ether; at 25 ℃; for 20h;
DOI:10.1002/ejoc.200400895

Reference yield: 80.0%

: 1214337-05-9
6-chloro-5-fluoro-2-picolinic acid methyl ester

: 860296-24-8
6-chloro-5-fluoro-pyridine-2-carboxylic acid

Guidance literature:: 6-chloro-5-fluoro-2-picolinic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water;