860296-23-7

Basic information

• Product Name: 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid
• Synonyms: 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid
• CAS NO: 860296-23-7
• Molecular Weight: 247.729
• Mol File: 860296-23-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid(860296-23-7)
• EPA Substance Registry System: 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid(860296-23-7)

Safety Data

• Hazardous Substances Data: 860296-23-7(Hazardous Substances Data)

Upstream product

• 860296-22-6 2-chloro-3-fluoro-4-(trimethylsilyl)pyridine 
• 124-38-9 carbon dioxide 
• 77332-77-5 3-fluoro-4-(trimethylsilyl)pyridine 
• 372-47-4 3-Fluoropyridine 

Downstream Products

• 107504-08-5 5-fluoropicolinic acid 
• 860296-24-8 6-chloro-5-fluoro-pyridine-2-carboxylic acid 

Relevant articles and documents

Converting core compounds into building blocks: The concept of regiochemically exhaustive functionalization

In a model study, 3-fluorophenol and 3-fluoropyridine were converted into the each time four possible carboxylic acids by passing through the corresponding organometallic intermediates. As an attempt to generalize the findings reveals, a restricted set of principles and methods suffices to cope with all standard scenarios. The most valuable and versatile tools for the regiochemically exhaustive functionalization of a great variety of substrate patterns are the optionally site-selective metalation (either by reagent/substrate matching or by peripheral coordination control), the use of activating or congesting protective groups and the basicity gradient-driven heavy halogen migration (followed by halogen/metal permutation). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.