LORATADINE HYDROCHLORIDE

Base Information

• Chemical Name: LORATADINE HYDROCHLORIDE
• CAS No.: 170727-59-0
• Molecular Formula: C22H23ClN2O2
• Molecular Weight: 419.34
• Mol file: 170727-59-0.mol

Synonyms:LORATADINE HYDROCHLORIDE;Iso Loratadine;4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-3,6-dihydro-1(2H)-pyridinecarboxylic Acid Ethyl Ester;Loratadine EP IMpurity E

Chemical Property of LORATADINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 512.6±50.0 °C(Predicted)
• PKA: 5.09±0.40(Predicted)
• PSA: 42.43000
• Density: 1.253±0.06 g/cm3(Predicted)
• LogP: 4.69200
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

IsoLoratadine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Iso Loratadine (Loratadine EP Impurity E) is a Loratadine (L469575) impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases. Loratadine (L469575) impurity, Loratadine EP Impurity E can be used as an isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.

Technology Process of LORATADINE HYDROCHLORIDE

There total 1 articles about LORATADINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

loratadine (79794-75-5) → 8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (38093-12-8) + ethyl 4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-5,6-dihydropyridine-1(2H)-carboxylate (170727-59-0) + N-ethoxycarbonyl-4-piperidone (29976-53-2)

Guidance literature:

In water; acetonitrile; for 0.333333h; Time; Kinetics; Quantum yield; Inert atmosphere; UV-irradiation;

DOI:10.1016/j.ecoenv.2018.11.116

upstream raw materials:

loratadine

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