LY-2608204

Base Information

• Chemical Name: LY-2608204
• CAS No.: 1234703-40-2
• Molecular Formula: C28H37N3O3S3
• Molecular Weight: 559.81
• Mol file: 1234703-40-2.mol

Synonyms:LY-2608204;(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide;(1R,2S)-2-cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropanecarboxaMide

Chemical Property of LY-2608204

Chemical Property:

• PSA: 144.78000
• Density: 1.35
• LogP: 7.41200
• Solubility.: ≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH

Purity/Quality:

98% min ^*data from raw suppliers

LY2608204 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: LY2608204 is an activator of glucokinase (GK; EC50 = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.

Technology Process of LY-2608204

There total 1 articles about LY-2608204 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-ylamine (1042777-99-0) + C19H23ClO3S → (1R,2S)-2-Cyclohexyl-1-(4-cyclopropanesulfonyl-phenyl)-cyclopropanecarboxylic acid [5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-yl]amide (1234703-40-2)

Guidance literature:

With sodium sulfate; triethylamine; In dichloromethane; at 5 - 20 ℃; Inert atmosphere;

upstream raw materials:

5-(2-pyrrolidin-1-yl-ethylsulfanyl)-thiazol-2-ylamine

Refernces