3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-

Base Information

• Chemical Name: 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-
• CAS No.: 137129-98-7
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• Mol file: 137129-98-7.mol

Synonyms:6-chloro-2-methylnicotinic acid;6-CHLORO-2-METHYLPYRIDINE-3-CARBOXYLIC ACID;

Chemical Property of 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 321.964°C at 760 mmHg
• PKA: 2.90±0.25(Predicted)
• Flash Point: 148.518°C
• PSA: 50.19000
• Density: 1.390±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.74160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

6-Chloro-2-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-

There total 1 articles about 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 6-chloro-2-methylnicotinate (31163-12-9) → 6-chloro-2-methylpyridine-3-carboxylic acid (137129-98-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm100348u

Reference yield: 95.0%

4-chloro-3-(pyridin-2-yl)benzeneamine (879088-41-2) + 6-chloro-2-methylpyridine-3-carboxylic acid (137129-98-7) → C18H13Cl2N3O (879088-87-6)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2010.08.134

Reference yield: 95.0%

piperidin-4-one (41661-47-6) + 6-chloro-2-methylpyridine-3-carboxylic acid (137129-98-7) → 1-(6-chloro-2-methylnicotinoyl)piperidin-4-one

Guidance literature:

With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

ethyl 6-chloro-2-methylnicotinate

Downstream raw materials:

6-chloro-N-cyclohexyl-2-methylnicotinamide

(2S)-1-[(6-chloro-2-methyl-3-pyridinyl)carbonyl]-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine

4-({(3S)-4-[(6-Chloro-2-methyl-3-pyridinyl)carbonyl]-3-methyl-1-piperazinyl}sulfonyl)-3-methylbenzonitrile

C₇H₅Cl₂NO