(2-Chloro-pyrimidin-4-yl)-cyclopropyl-amine

Base Information

• Chemical Name: (2-Chloro-pyrimidin-4-yl)-cyclopropyl-amine
• CAS No.: 945895-52-3
• Molecular Formula: C₇H₈ClN₃
• Molecular Weight: 169.614
• Hs Code.: 2933599090
• Mol file: 945895-52-3.mol

Synonyms:2-Chloro-4-(cyclopropylaMino)pyriMidine;

Chemical Property of (2-Chloro-pyrimidin-4-yl)-cyclopropyl-amine

Chemical Property:

• Melting Point: 125-130°C
• PSA: 41.04000
• Density: 1.454
• LogP: 1.12620
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-(cyclopropylamino)pyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Chloro-pyrimidin-4-yl)-cyclopropyl-amine

There total 2 articles about (2-Chloro-pyrimidin-4-yl)-cyclopropyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-Dichloropyrimidine (3934-20-1) + Cyclopropylamine (765-30-0) → 2-chloro-N-cyclopropylpyrimidin-4-amine (945895-52-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2019.126885

Reference yield: 63.7%

2,6-Dichloropyrimidine (3934-20-1) + Cyclopropylamine (765-30-0) → 2-chloro-N-cyclopropylpyrimidin-4-amine (945895-52-3) + 4-chloro-N-cyclopropylpyrimidin-2-amine (1044771-76-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; Inert atmosphere; Cooling;

DOI:10.1021/acs.jmedchem.6b01448

Reference yield:

2-chloro-N-cyclopropylpyrimidin-4-amine (945895-52-3) → 1-(4-cyanophenyl)-3-(3-(4-(cyclopropylamino)pyrimidin-2-yl)phenyl)urea

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 10 h / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C

3: dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; 1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.6b01448

upstream raw materials:

2,6-Dichloropyrimidine

Cyclopropylamine