1-(2-MethylpyriMidin-5-yl)ethanaMine

Base Information

• Chemical Name: 1-(2-MethylpyriMidin-5-yl)ethanaMine
• CAS No.: 1071435-99-8
• Molecular Formula: C7H11N3
• Molecular Weight: 137
• Hs Code.: 2933599090
• Mol file: 1071435-99-8.mol

Synonyms:1-(2-MethylpyriMidin-5-yl)ethanaMine;α,2-DiMethyl-5-pyriMidineMethanaMine

Chemical Property of 1-(2-MethylpyriMidin-5-yl)ethanaMine

Chemical Property:

• Boiling Point: 219℃
• Flash Point: 109℃
• PSA: 51.80000
• Density: 1.060
• LogP: 1.50500
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Methylpyrimidin-5-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A pyrimidine derivative, 1-(2-MethylpyriMidin-5-yl)ethanaMine can be used in the preparation of heterocyclic analgesic compounds. A pyrimidine derivative used in the preparation of heterocyclic analgesic compounds.

Technology Process of 1-(2-MethylpyriMidin-5-yl)ethanaMine

There total 3 articles about 1-(2-MethylpyriMidin-5-yl)ethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(1-azidoethyl)-2-methylpyrimidine (1071435-98-7) → 1-(2-methylpyrimidin-5-yl)ethanamine (1071435-99-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; under 760.051 Torr;

Reference yield:

2-methyl-5-pyrimidinecarbaldehyde (90905-33-2) → 1-(2-methylpyrimidin-5-yl)ethanamine (1071435-99-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 760.05 Torr

With diphenyl phosphoryl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; toluene;

Reference yield:

1-(2-methylpyrimidin-5-yl)ethanol (1071435-96-5) → 1-(2-methylpyrimidin-5-yl)ethanamine (1071435-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 760.05 Torr

With diphenyl phosphoryl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In ethyl acetate; toluene;

upstream raw materials:

5-(1-azidoethyl)-2-methylpyrimidine

2-methyl-5-pyrimidinecarbaldehyde

1-(2-methylpyrimidin-5-yl)ethanol

Refernces

• 1、 -. "PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF". Page/Page column 57. . Retrieved 2008/12/04.