2-(Bromomethyl)-3-chloropyrazine

Base Information

Chemical Name:2-(Bromomethyl)-3-chloropyrazine
CAS No.:1289386-07-7
Molecular Formula:C₅H₄BrClN₂
Molecular Weight:207.457
Hs Code.:
DSSTox Substance ID:DTXSID70693746
Wikidata:Q72446951
Mol file:1289386-07-7.mol

Synonyms:2-(bromomethyl)-3-chloropyrazine;1289386-07-7;2-Bromomethyl-3-chloro-pyrazine;SCHEMBL16701558;DTXSID70693746;RZFUYJOAJOPEDH-UHFFFAOYSA-N;2-(Bromomethyl)-3-chloro-pyrazine;AKOS015940526;AM91562;FT-0758920

Suppliers and Price of 2-(Bromomethyl)-3-chloropyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-BROMOMETHYL-3-CHLORO-PYRAZINE 95.00%
5MG
$ 495.73

Total 6 raw suppliers

Chemical Property of 2-(Bromomethyl)-3-chloropyrazine

Chemical Property:

Boiling Point:243℃
Flash Point:101℃
PSA：25.78000
Density:1.768
LogP:2.02490
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:205.92464
Heavy Atom Count:9
Complexity:91

Purity/Quality:

98% ^*data from raw suppliers

2-BROMOMETHYL-3-CHLORO-PYRAZINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C(=N1)CBr)Cl

Technology Process of 2-(Bromomethyl)-3-chloropyrazine

There total 1 articles about 2-(Bromomethyl)-3-chloropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 95-58-9
2-chloro-3-methylpyrazine

: 1289386-07-7
2-(3-chloropyrazinyl)methyl bromide

Guidance literature:: With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 1289386-07-7
2-(3-chloropyrazinyl)methyl bromide

: 1419221-81-0
benzyl (3R)-3-(8-amino-1-(4-[(pyridin-2-yl)carbamoyl]phenyl)imidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 60 °C

2.1: hydrazine hydrate / methanol / 2 h / 60 °C

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 20 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C / Cooling with ice

5.1: trichlorophosphate; 1,3-dimethyl-2-imidazolidinone / acetonitrile / 12 h / 0 - 60 °C

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

7.1: ammonia / isopropyl alcohol; dimethyl sulfoxide / 80 °C

8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / Reflux

With 1,3-dimethyl-2-imidazolidinone; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; sodium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid; trichlorophosphate; In methanol; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1289386-07-7
2-(3-chloropyrazinyl)methyl bromide

: (R)-N-(pyridin-2-yl)-p-(3-(piperidin-3-yl)-8-aminoimidazo[1,5-a]pyrazin-1-yl)benzamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide / 60 °C

2.1: hydrazine hydrate / methanol / 2 h / 60 °C

3.1: triethylamine / dichloromethane / 0.17 h / Cooling with ice

3.2: 20 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: 20 °C / Cooling with ice

5.1: trichlorophosphate; 1,3-dimethyl-2-imidazolidinone / acetonitrile / 12 h / 0 - 60 °C

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

7.1: ammonia / isopropyl alcohol; dimethyl sulfoxide / 80 °C

8.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / Reflux

9.1: hydrogen bromide; acetic acid / 1,2-dimethoxyethane / 1 h / 20 °C

With 1,3-dimethyl-2-imidazolidinone; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonia; hydrogen bromide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; trichlorophosphate; In methanol; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;