95-58-9

Basic information

• Product Name: 2-CHLORO-3-METHYLPYRAZINE
• Synonyms: 2-CHLORO-3-METHYLPYRAZINE;2-CHLORO-3,(5),(6)-ETHYLPYRAZINE;2-Methyl-3-chloropyrazine;Pyrazine, 2-chloro-3-methyl-
• CAS NO: 95-58-9
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• EINECS: 202-434-8
• Product Categories: Piperazine series;Pyrazines
• Mol File: 95-58-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 169.5 °C at 760 mmHg
• Flash Point: 70.2 °C
• Appearance: Colorless/Liquid
• Density: 1.234 g/cm³
• Vapor Pressure: 2.035mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.31±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-METHYLPYRAZINE(95-58-9)
• EPA Substance Registry System: 2-CHLORO-3-METHYLPYRAZINE(95-58-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• TSCA: Yes
• Hazardous Substances Data: 95-58-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-methylpyrazine is a chemical compound with the formula C5H6ClN2. It is a colorless to pale yellow liquid that is commonly used as a flavoring agent in the food industry. It has a strong, earthy, and nutty odor and is commonly used in the production of various food products, including coffee, chocolate, and savory snacks. The compound is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Additionally, 2-chloro-3-methylpyrazine has been identified as a potential component in tobacco smoke and is subject to regulation as an additive in tobacco products.

InChI:InChI=1/C5H5ClN2/c1-4-5(6)8-3-2-7-4/h2-3H,1H3

Upstream product

• 534-26-9 lysidine 
• 67-66-3 chloroform 
• 930-61-0 2,4-dimethyl-2-imidazoline 
• 7664-93-9 sulfuric acid 
• 19838-07-4 3-methyl-2-hydroxypyrazine 
• 109-08-0 2-Methylpyrazine 
• 693-98-1 2-methylimidazole 
• 19838-07-4 3-methylpyrazin-2(1H)-one 

Downstream Products

• 2882-20-4 2-methyl-3-(methylthio)pyrazine 
• 74990-49-1 benzylthio-2 methyl-3 pyrazine 
• 1289384-62-8 tert-butyl 4-[(3-methylpyrazin-2-yl)amino]piperidine-1-carboxylate 
• 1289385-32-5 tert-butyl 3-[(3-methylpyrazin-2-yl)amino]piperidine-1-carboxylate 
• 1419221-81-0 benzyl (3R)-3-(8-amino-1-(4-[(pyridin-2-yl)carbamoyl]phenyl)imidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate 
• 1418307-23-9 benzyl (2S)-2-([(3-chloropyrazin-2-yl)methyl]carbamoyl)piperidine-1-carboxylate 
• 1419221-80-9 benzyl (R)-3-(8-amino-1-bromoimidazo[1,5-a]-pyrazin-3-yl)piperidine-1-carboxylate 
• 1419221-79-6 benzyl (3R)-3-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate 
• 1419221-78-5 benzyl (3R)-3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate 
• 1419221-77-4 benzyl (3R)-3-([(3-chloropyrazin-2-yl)methyl]carbamoyl)piperidine-1-carboxylate 
• 1420478-88-1 benzyl (2S)-2-(8-amino-1-bromo-imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Production method of 2-methyl-3(5 or 6)-methylthio pyrazine

The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.

N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists

The invention concerns pharmaceutically useful N-heterocyclyl sulphonamide derivatives, their pharmaceutically acceptable salts, processes for their manufacture, their use for antagonising one or more actions of endothelin in a human or other warm-blooded animal, their use in methods of treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role.

Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

The vapor-phase reactions of imidazolines and anils with chloroform at 550 deg C are compared with their liquid-phase reactions in the presence of hexachloroacetone and base or upon thermolysis with trichloroacetate ion.In the vapour-phase reactions imidazolines, unlike imidazoles, gave non-chlorinated pyrimidines, and 1-methyl-imidazole gave 2-cyanopyrrole and the four 3-chlorocyanopyridines.