8-Bromo-2,4-dichloroquinoline

Base Information

• Chemical Name: 8-Bromo-2,4-dichloroquinoline
• CAS No.: 406204-86-2
• Molecular Formula: C₉H₄BrCl₂N
• Molecular Weight: 276.947
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID00697474
• Wikidata: Q82627384
• Mol file: 406204-86-2.mol

Synonyms:8-BROMO-2,4-DICHLOROQUINOLINE;406204-86-2;SCHEMBL7697568;DTXSID00697474;AMY26452;MFCD15526788;AKOS016006518;8-Bromo-2,4-dichloroquinoline, 97%;SB71683;AS-41315;CS-0136685;EN300-645229;A850228

Chemical Property of 8-Bromo-2,4-dichloroquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 4.30410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 274.89042
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-2,4-dichloroquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)Br)N=C(C=C2Cl)Cl

Technology Process of 8-Bromo-2,4-dichloroquinoline

There total 1 articles about 8-Bromo-2,4-dichloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

malonic acid (141-82-2) + 2-bromoaniline (615-36-1) → 8-bromo-2,4-dichloro-quinoline (406204-86-2)

Guidance literature:

With trichlorophosphate; for 5h; Heating;

DOI:10.1016/j.bmcl.2005.07.044

Reference yield:

8-bromo-2,4-dichloro-quinoline (406204-86-2) → 2,4-dimethoxy-8-phenyl-quinoline

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / methanol / 48 h / Heating

2: 90 percent / tetrakis(triphenylphosphine)palladium; aq. sodium carbonate / toluene; ethanol / 48 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; ethanol; toluene; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2005.07.044

Reference yield:

8-bromo-2,4-dichloro-quinoline (406204-86-2) → 2,4-dimethoxy-8-(4-methoxy-phenyl)-quinoline

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / methanol / 48 h / Heating

2: tetrakis(triphenylphosphine)palladium; aq. sodium carbonate / toluene; ethanol / 48 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; ethanol; toluene; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2005.07.044

upstream raw materials:

malonic acid

2-bromoaniline

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