1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Base Information

• Chemical Name: 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• CAS No.: 1029716-44-6
• Molecular Formula: C13H23BN2O3
• Molecular Weight: 266.148
• Hs Code.: 2934999090
• Mol file: 1029716-44-6.mol

Synonyms:1-(1-Ethoxyethyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester; (1-(1-ETHOXYETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

Chemical Property of 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property:

• Boiling Point: 353.3±22.0 °C(Predicted)
• PKA: 1.55±0.10(Predicted)
• PSA: 45.51000
• Density: 1.06
• LogP: 1.73730
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(1-Ethoxyethyl)-1H-pyrazole-4-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

There total 6 articles about 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole (1024120-52-2) → 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1029716-44-6)

Guidance literature:

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 3h;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 99.0%

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole (1024120-52-2) + 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1195-66-0) → 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1029716-44-6)

Guidance literature:

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole; With isopropyl magnesium chloride - lithium chloride complex; In tetrahydrofuran; at 20 - 25 ℃; for 16h;

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -20 - 25 ℃; for 2h;

Reference yield: 97.3%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + ethyl vinyl ether (109-92-2,25104-37-4) → 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (1029716-44-6)

Guidance literature:

pyrazole-4-boronic acid pinacol ester; ethyl vinyl ether; With hydrogenchloride; In 1,4-dioxane; toluene; at 35 - 40 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; toluene; for 1h; Product distribution / selectivity;

upstream raw materials:

4-bromo-1-(1-ethoxyethyl)-1H-pyrazole

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-(1-ethoxyethyl)-4-iodo-1H-pyrazole

Downstream raw materials:

4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

1-{4-chloro-6-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-3',5'-difluorobiphenyl-2-yl}ethanamine