Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate
• CAS No.: 657424-68-5
• Molecular Formula: C11H9ClN2O3
• Molecular Weight: 252.657
• Hs Code.: 2934999090
• Mol file: 657424-68-5.mol

Synonyms:Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate;5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester;

Chemical Property of Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate

Chemical Property:

• PSA: 65.22000
• LogP: 2.56670
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate

There total 2 articles about Ethyl 5-(3-chlorophenyl)-[1,2,4]oxadiazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

2-(3-chloro-phenyl)-4-dimethylaminomethylene-4H-oxazol-5-one (373618-95-2) + ethanol (64-17-5) → 5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (657424-68-5)

Guidance literature:

2-(3-chloro-phenyl)-4-dimethylaminomethylene-4H-oxazol-5-one; ethanol; With sodium hydroxide; for 0.5h; Heating / reflux;

With hydrogenchloride; sodium nitrite; In diethyl ether; water;

Reference yield:

m-chlorobenzene carboxamidoacetic acid (57728-59-3) → 5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (657424-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 1 h / 0 - 50 °C

2: sodium hydroxide / 0.5 h / Heating / reflux

With sodium hydroxide; trichlorophosphate;

Reference yield: 25.0%

5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester (657424-68-5) → 5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carbaldehyde (657424-70-9)

Guidance literature:

5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester; With diisobutylaluminium hydride; In hexanes; dichloromethane; at -78 ℃; for 0.666667h;

With Rochelle's salt; In hexanes; dichloromethane; water; at 0 - 20 ℃;

upstream raw materials:

2-(3-chloro-phenyl)-4-dimethylaminomethylene-4H-oxazol-5-one

ethanol

m-chlorobenzene carboxamidoacetic acid

Downstream raw materials:

5-(3-chloro-phenyl)-[1,2,4]oxadiazole-3-carbaldehyde

methanesulfonic acid 1-[5-(3-chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-ethyl ester

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