7-Methyl-2,7-diazaspiro[3.5]nonane

Base Information

• Chemical Name: 7-Methyl-2,7-diazaspiro[3.5]nonane
• CAS No.: 135380-50-6
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60451155
• Wikidata: Q82271035
• Mol file: 135380-50-6.mol

Synonyms:7-methyl-2,7-diazaspiro[3.5]nonane;135380-50-6;2,7-Diazaspiro[3.5]nonane, 7-methyl-;2,7-Diazaspiro[3.5]nonane,7-methyl-;7-Methyl-2,7-diaza-spiro[3.5]nonane;SCHEMBL993857;DTXSID60451155;QOIARYNCRPZCTG-UHFFFAOYSA-N;MFCD13180696;AKOS006353864;SB15895;CS-0000628;P11605;EN300-1700303

Chemical Property of 7-Methyl-2,7-diazaspiro[3.5]nonane

Chemical Property:

• Vapor Pressure: 0.00036mmHg at 25°C
• Boiling Point: 318.5°C at 760 mmHg
• PKA: 10.76±0.20(Predicted)
• Flash Point: 135.6°C
• PSA: 15.27000
• Density: 1.07g/cm³
• LogP: 0.56830
• Storage Temp.: 2-8°C
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 140.131348519
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

98%min ^*data from raw suppliers

7-Methyl-2,7-diazaspiro[3.5]nonane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2(CC1)CNC2

Technology Process of 7-Methyl-2,7-diazaspiro[3.5]nonane

There total 8 articles about 7-Methyl-2,7-diazaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-methyl-4-<<4-methylphenylsulfonyl>oxy>methyl-4-piperidinecarbonitrile (157736-58-8) → 7-methyl-2,7-diazaspiro<3.5>-nonane (135380-50-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 35 ℃; for 1h;

Reference yield: 37.0%

→ 7-methyl-2,7-diazaspiro<3.5>-nonane (135380-50-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

7-methyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (1093066-77-3) → 7-methyl-2,7-diazaspiro<3.5>-nonane (135380-50-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

upstream raw materials:

1-methyl-4-<<4-methylphenylsulfonyl>oxy>methyl-4-piperidinecarbonitrile

1-methylpiperidine-4-carbonitrile

4-hydroxymethyl-1-methyl-4-piperidinecarbonitrile

7-methyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 323; 328. . Retrieved 2019/11/19.
• 2、 -. "THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS". Page/Page column 81-82. . Retrieved 2009/05/28.