Technology Process of 2,7-Diazaspiro[3.5]nonane-2-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester
There total 3 articles about 2,7-Diazaspiro[3.5]nonane-2-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; 2-(tert-butoxycarbonyl)-2,7-diazaspiro[3.5]nonan-7-ium hydrochloride;
In
water; 1,2-dichloro-ethane;
at 20 ℃;
for 0.166667h;
With
sodium tris(acetoxy)borohydride;
In
water; 1,2-dichloro-ethane;
for 1h;
With
ammonia;
In
methanol;
- Guidance literature:
-
2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester; formaldehyd;
In
tetrahydrofuran; water;
for 0.5h;
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 0 - 20 °C / 760.05 Torr
2.1: tetrahydrofuran; water / 0.5 h
2.2: 20 °C
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; methanol; water;