(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

Base Information

• Chemical Name: (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
• CAS No.: 1032754-93-0
• Molecular Formula: C23H30N8O3S
• Molecular Weight: 498.609
• Mol file: 1032754-93-0.mol

Synonyms:(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one;

Chemical Property of (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

Chemical Property:

• Boiling Point: 718.6±70.0 °C at 760 mmHg
• PKA: 13.90±0.20(Predicted)
• Flash Point: 388.4±35.7 °C
• PSA: 162.80000
• Density: 1.4±0.1 g/cm³
• LogP: 0.77140
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

GDC-0980 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GDC-0980 is used in the synthesis of PI3K inhibitors to treat carcinomas. Potent PI3K/mTOR dual Inhibitor.

Technology Process of (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

There total 3 articles about (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2-aminopyrimidin-5-yl)boronic acid (936250-22-5) + (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one (1032757-58-6) → [14C]-GDC-0980 (1032754-93-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In propan-1-ol; water; at 20 - 85 ℃; for 2.5h; pH=6 - 8; Reagent/catalyst; Solvent; Concentration; Inert atmosphere;

DOI:10.1021/op500366s

Reference yield:

propan-1-ol (71-23-8) + potassium phosphate + bis(triphenylphosphine)palladium(II) dichloride + (2-aminopyrimidin-5-yl)boronic acid (936250-22-5) + (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one (1032757-58-6) → [14C]-GDC-0980 (1032754-93-0)

Guidance literature:

In water;

Reference yield:

propan-1-ol (71-23-8) + bis(triphenylphosphine)palladium(II) dichloride + dipotassium hydrogen phosphate + (2-aminopyrimidin-5-yl)boronic acid (936250-22-5) + (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one (1032757-58-6) → [14C]-GDC-0980 (1032754-93-0)

Guidance literature:

In water;

upstream raw materials:

propan-1-ol

(2-aminopyrimidin-5-yl)boronic acid

(S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one