GTx-134

Base Information

Chemical Name:GTx-134
CAS No.:1008448-19-8
Molecular Formula:C₃₃H₄₀N₆O₆S
Molecular Weight:648.783
Hs Code.:
Mol file:1008448-19-8.mol

Synonyms:GTx-134

Suppliers and Price of GTx-134

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of GTx-134

Chemical Property:

PSA：169.36000
Density:1.43
LogP:4.29350

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of GTx-134

There total 12 articles about GTx-134 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: (R)-2-(4-((3-(2,4-dimethylphenoxy)-2-hydroxypropyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-6-(piperidin-4-yl)-6,7-dihydroimidazo[4,5-f]isoindol-5(3H)-one

: 3680-02-2
methyl ethenyl sulphone

: 1008448-19-8
2-{4-[(R)-3-(2,4-dimethylphenoxy)-2-hydroxypropylamino]-2-oxo-1,2-dihydropyridin-3-yl}-6-[1-(2-methanesulfonylethyl)piperidin-4-yl]-6,7-dihydro-3H-1,3,6-triaza-s-indacen-5-one

Guidance literature:: In ethanol; isopropyl alcohol; at 100 ℃; for 22h;
DOI:10.1002/jhet.2443

Reference yield:

: 59827-85-9
5-amino-6-nitroisoindoline-1,3-dione

: 1008448-19-8
2-{4-[(R)-3-(2,4-dimethylphenoxy)-2-hydroxypropylamino]-2-oxo-1,2-dihydropyridin-3-yl}-6-[1-(2-methanesulfonylethyl)piperidin-4-yl]-6,7-dihydro-3H-1,3,6-triaza-s-indacen-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / 1,4-dioxane / 72 h / 140 °C / Sealed tube

2.1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol; methanol / 20 °C

3.1: acetic acid; oxygen / methanol / 72 h / 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 4 h / 70 °C

4.2: 20 h / 0 - 20 °C / Inert atmosphere

4.3: 14 h / 100 °C

5.1: acetic acid; zinc / Reflux

6.1: hydrogenchloride / 1,4-dioxane / 1 h / 90 °C

7.1: isopropyl alcohol; ethanol / 22 h / 100 °C

With 1H-imidazole; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; oxygen; acetic acid; zinc; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol;
DOI:10.1002/jhet.2443

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1008448-19-8
2-{4-[(R)-3-(2,4-dimethylphenoxy)-2-hydroxypropylamino]-2-oxo-1,2-dihydropyridin-3-yl}-6-[1-(2-methanesulfonylethyl)piperidin-4-yl]-6,7-dihydro-3H-1,3,6-triaza-s-indacen-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / 1,4-dioxane / 72 h / 140 °C / Sealed tube

2.1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol; methanol / 20 °C

3.1: acetic acid; oxygen / methanol / 72 h / 20 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 4 h / 70 °C

4.2: 20 h / 0 - 20 °C / Inert atmosphere

4.3: 14 h / 100 °C

5.1: acetic acid; zinc / Reflux

6.1: hydrogenchloride / 1,4-dioxane / 1 h / 90 °C

7.1: isopropyl alcohol; ethanol / 22 h / 100 °C

With 1H-imidazole; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; oxygen; acetic acid; zinc; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol;
DOI:10.1002/jhet.2443