tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Base Information

• Chemical Name: tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate
• CAS No.: 1059172-92-7
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.27
• Hs Code.: 2933990090
• Mol file: 1059172-92-7.mol

Synonyms:tert-Butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate;

Chemical Property of tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Chemical Property:

• PSA: 42.43000
• LogP: 2.27020

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate 95+% ^*data from reagent suppliers

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Technology Process of tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

There total 2 articles about tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

di-tert-butyl dicarbonate (24424-99-5) + 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (147739-88-6) → tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate (1059172-92-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 10.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine (109966-30-5) → tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate (1059172-92-7)

Guidance literature:

With hydrogen; 20 % Pd(OH)2/C; In methanol; at 60 ℃; under 11400.8 Torr; Autoclave;

Reference yield: 65.0%

tert-butyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate (1059172-92-7) → tert-butyl hexahydro-1H-pyrrolo[3.4-b]pyridine-6(2H)-carboxylate (186203-81-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In 2-methoxy-ethanol; at 70 ℃; for 6h;

upstream raw materials:

di-tert-butyl dicarbonate

6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

Downstream raw materials:

tert-butyl hexahydro-1H-pyrrolo[3.4-b]pyridine-6(2H)-carboxylate

tert-butyl 1-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydro-1H-pyrrolo[3,4-b] pyridine-6(2H)-carboxylate

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(octahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)propoxy)quinazolin-4-amine

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(6-methyloctahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)propoxy)quinazolin-4-amine

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