2-(propylamino)isonicotinonitrile

Base Information

• Chemical Name: 2-(propylamino)isonicotinonitrile
• CAS No.: 127680-76-6
• Molecular Formula: C9H11N3
• Molecular Weight: 161.206
• Hs Code.: 2933399090
• Mol file: 127680-76-6.mol

Synonyms:2-(propylamino)isonicotinonitrile

Chemical Property of 2-(propylamino)isonicotinonitrile

Chemical Property:

• PSA: 51.94000
• LogP: 1.19708
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

2-(Propylamino)isonicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(propylamino)isonicotinonitrile

There total 2 articles about 2-(propylamino)isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

propylamine (107-10-8,42939-71-9) + 2-chloro-4-pyridinenitrile (33252-30-1) → 2-(propylamino)isonicotinonitrile (127680-76-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 130 ℃; for 25h;

DOI:10.1016/j.bmc.2005.03.052

Reference yield:

propylamine (107-10-8,42939-71-9) + 2,4-Dicyanopyridine (29181-50-8) → 2-Cyanopyridine (100-70-9,1232006-36-8) + 2-(propylamino)isonicotinonitrile (127680-76-6) + 4-Propylamino-pyridine-2-carbonitrile (127680-75-5)

Guidance literature:

In water; acetonitrile; for 2.5h; Product distribution; Mechanism; Irradiation; other reaction time; other primary and secondary amines;

DOI:10.1039/P19900000097

Reference yield:

2-(propylamino)isonicotinonitrile (127680-76-6) → 6-[4-(3-fluoro-benzyloxy)-phenoxy]-N-(2-propylamino-pyridin-4-ylmethyl)-nicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / ammonia; Raney Ni; H₂ / methanol; H₂O / 3 h / 20 °C / 2500.73 Torr

2: 69 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 20 °C

With ammonia; hydrogen; nickel; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.03.052

upstream raw materials:

propylamine

2,4-Dicyanopyridine

2-chloro-4-pyridinenitrile

Refernces

• 1、 Bernardi, Rosanna,Caronna, Tullio,Morrocchi, Sergio,Ursini, Maurizio,Vittimberga, Bruno M.. "A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines". . p. 97 - 100. Retrieved 2007/10/02.