2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE

Base Information

• Chemical Name: 2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE
• CAS No.: 38203-11-1
• Molecular Formula: C8H8N2
• Molecular Weight: 132.16
• Hs Code.: 2933399090
• Mol file: 38203-11-1.mol

Synonyms:2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE;(3-methyl-pyridin-2-yl)-acetonitrile

Chemical Property of 2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE

Chemical Property:

• Vapor Pressure: 0.015mmHg at 25°C
• Boiling Point: 256.502°C at 760 mmHg
• Flash Point: 98.7°C
• PSA: 36.68000
• Density: 1.056g/cm³
• LogP: 1.45608
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(3-Methylpyridin-2-yl)acetonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE

There total 2 articles about 2-(3-METHYLPYRIDIN-2-YL)ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-3-picoline (3430-17-9) + acetonitrile (75-05-8,26809-02-9) → (3-methyl-pyridin-2-yl)-acetonitrile (38203-11-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 2.08333h;

Reference yield:

→ (3-methyl-pyridin-2-yl)-acetonitrile (38203-11-1)

Guidance literature:

entspr. 2-Chlormethylpyridin, NaCN;

DOI:10.1002/mrc.1270040208

Reference yield: 91.0%

(3-methyl-pyridin-2-yl)-acetonitrile (38203-11-1) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-(3-methylpyridin-2-yl)acetate (1092477-78-5)

Guidance literature:

(3-methyl-pyridin-2-yl)-acetonitrile; With hydrogenchloride; water; at 90 ℃; for 1h;

diazomethyl-trimethyl-silane; With methanol; In hexane; at 20 ℃; for 1h;

upstream raw materials:

2-bromo-3-picoline

acetonitrile

Downstream raw materials:

methyl 2-(3-methylpyridin-2-yl)acetate

(+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(4-methyl-1-piperazinyl)-2-(3-methyl-2-pyridinyl)acetohydrazide

(R)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(4-methyl-1-piperazinyl)-2-(3-methyl-2-pyridinyl)acetohydrazide

(S)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(4-methyl-1-piperazinyl)-2-(3-methyl-2-pyridinyl)acetohydrazide

Refernces

• 1、 -. "Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof". Page/Page column 79. . Retrieved 2008/06/13.