4-Chloro-2-iodo-benzaldehyde

Base Information

• Chemical Name: 4-Chloro-2-iodo-benzaldehyde
• CAS No.: 132901-37-2
• Molecular Formula: C7H4ClIO
• Molecular Weight: 266.466
• Mol file: 132901-37-2.mol

Synonyms:4-Chloro-2-iodo-benzaldehyde;

Chemical Property of 4-Chloro-2-iodo-benzaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 2.75710

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-2-iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-iodo-benzaldehyde

There total 3 articles about 4-Chloro-2-iodo-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-chloro-2-iodophenyl)methanol (244104-55-0) → 4-chloro-2-iodobenzaldehyde (132901-37-2)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00752

Reference yield: 42.0%

4,4-dimethyl-2-(4-chloro-2-iodophenyl)-2-oxazoline (56446-21-0) → 4-chloro-2-iodobenzaldehyde (132901-37-2)

Guidance literature:

4,4-dimethyl-2-(4-chloro-2-iodophenyl)-2-oxazoline; With methyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; at 0 ℃; for 1h; Further stages; Inert atmosphere;

DOI:10.1002/anie.200902884

Reference yield:

4-chloro-2-iodobenzoic acid (13421-13-1) → 4-chloro-2-iodobenzaldehyde (132901-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.orglett.5b00554

upstream raw materials:

4,4-dimethyl-2-(4-chloro-2-iodophenyl)-2-oxazoline

(4-chloro-2-iodophenyl)methanol

4-chloro-2-iodobenzoic acid

Downstream raw materials:

tert-butyl 2-diazo-3-(4-chloro-2-iodophenyl)-3-hydroxypropionate

1-(4-chloro-2-iodophenyl)ethanol

N-(4-chloro-2-iodobenzylidene)tert-butylamine

1-(4-chloro-2-iodophenyl)hept-2-yn-1-one