Oglemilast

Base Information

Chemical Name:Oglemilast
CAS No.:778576-62-8
Molecular Formula:C₂₀H₁₃Cl₂F₂N₃O₅S
Molecular Weight:516.309
Hs Code.:
UNII:67GXQ6WCC6
ChEMBL ID:CHEMBL4297520
DSSTox Substance ID:DTXSID70999058
Metabolomics Workbench ID:153370
NCI Thesaurus Code:C87376
Pharos Ligand ID:WBWVN9R11TKB
Wikidata:Q27264129
Mol file:778576-62-8.mol

Synonyms:GRC 3886;GRC-3886;GRC3886;oglemilast

Suppliers and Price of Oglemilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide 95+%
250mg
$ 742.00

Matrix Scientific
N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide 95+%
1g
$ 1647.00

DC Chemicals
Oglemilast >98%
250 mg
$ 1100.00

Crysdot
Oglemilast 98+%
50mg
$ 765.00

Crysdot
Oglemilast 98+%
5mg
$ 255.00

Crysdot
Oglemilast 98+%
10mg
$ 380.00

ChemScene
Oglemilast 98.20%
50mg
$ 612.00

ChemScene
Oglemilast 98.20%
10mg
$ 307.00

ChemScene
Oglemilast 98.20%
5mg
$ 182.00

Biosynth Carbosynth
Oglemilast
5 mg
$ 135.00

Total 13 raw suppliers

Chemical Property of Oglemilast

Chemical Property:

PKA:7.10±0.30(Predicted)
PSA：118.91000
Density:1.653
LogP:6.73980
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:514.9921034
Heavy Atom Count:33
Complexity:810

Purity/Quality:

97% ^*data from raw suppliers

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CS(=O)(=O)NC1=CC2=C(C=C1)OC3=C(C=CC(=C23)C(=O)NC4=C(C=NC=C4Cl)Cl)OC(F)F
Recent ClinicalTrials:Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Technology Process of Oglemilast

There total 2 articles about Oglemilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 685875-03-0
N₁-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-amino-dibenzo[b,d]furan-1-carboxamide

: 124-63-0
methanesulfonyl chloride

: 778576-62-8
N1-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-(methanesulfonamide)-dibenzo[b,d]furan-1-carboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 25 - 35 ℃; for 6.5h;

Reference yield: 81.1%

: 124-63-0
methanesulfonyl chloride

: 778576-62-8
N1-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-(methanesulfonamide)-dibenzo[b,d]furan-1-carboxamide

Guidance literature:: N₁-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-amino-dibenzo[b,d]furan-1-carboxamide; With pyridine; In tetrahydrofuran; for 0.25h;

methanesulfonyl chloride; In tetrahydrofuran; at 20 ℃;